M
Marian A. Martínez‐Balbás
Researcher at University of Cambridge
Publications - 9
Citations - 1318
Marian A. Martínez‐Balbás is an academic researcher from University of Cambridge. The author has contributed to research in topics: Medicine & Chromatin. The author has an hindex of 6, co-authored 6 publications receiving 1283 citations.
Papers
More filters
Journal ArticleDOI
Regulation of E2F1 activity by acetylation
TL;DR: It is suggested that acetylation stimulates the functions of the non‐RB bound ‘free’ form of E2F1, and it is found that the RB‐associated histone de acetylase can deacetylate E2f1.
Journal ArticleDOI
The acetyltransferase activity of CBP stimulates transcription
Marian A. Martínez‐Balbás,Andrew J. Bannister,Klaus Martin,Philipp Haus-Seuffert,Michael Meisterernst,Tony Kouzarides +5 more
TL;DR: It is shown that a region of CBP, encompassing the previously defined histone AT (HAT) domain, can stimulate transcription when tethered to a promoter and the stimulatory effect of this activation domain shows some promoter preference and is dependent on AT activity.
Journal ArticleDOI
E1A directly binds and regulates the P/CAF acetyltransferase.
Juliet L. Reid,Andrew J. Bannister,Philip Zegerman,Marian A. Martínez‐Balbás,Tony Kouzarides +4 more
TL;DR: The P/CAF protein has intrinsic histone acetyltransferase (HAT) activity and is capable of binding the transcriptional co‐activator CBP, but it is shown that it can regulate transcription and that this function is independent of its binding to CBP.
Journal ArticleDOI
Role of Histone Modifications in Marking and Activating Genes through Mitosis
TL;DR: A critical role of histone acetylation and H3 (Lys-4) methylation during mitosis is demonstrated in marking and activating genes during the mitotic stage of the cell cycle.
Journal ArticleDOI
Mechanisms of P/CAF auto-acetylation
TL;DR: The findings identify a new post-translation modification on P/CAF which may regulate its function and leads to an increment of its histone acetyltransferase (HAT) activity.