A
Alexander Brehm
Researcher at University of Marburg
Publications - 61
Citations - 8319
Alexander Brehm is an academic researcher from University of Marburg. The author has contributed to research in topics: Chromatin & Nucleosome. The author has an hindex of 36, co-authored 60 publications receiving 7940 citations. Previous affiliations of Alexander Brehm include University of Rochester & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Retinoblastoma protein recruits histone deacetylase to repress transcription
Alexander Brehm,Eric A. Miska,Dennis J. McCance,Dennis J. McCance,Juliet L. Reid,Andrew J. Bannister,Tony Kouzarides +6 more
TL;DR: It is shown that Rb associates with a histone deacetylase, HDAC1, through the Rb ‘pocket’ domain, and that active transcriptional repression by Rb may involve the modification of chromatin structure.
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DNA methyltransferase Dnmt1 associates with histone deacetylase activity.
TL;DR: A transcriptional repression domain in Dnmt1 is identified that functions, at least partly, by recruiting histone deacetylase activity and shows homology to the repressor domain of the trithorax-related protein HRX (also known as MLL and ALL-1).
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Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells
Young Il Yeom,Guy Fuhrmann,Catherine E. Ovitt,Alexander Brehm,Kazuyuki Ohbo,Michael K. Gross,Karin Hübner,Hans R. Schöler +7 more
TL;DR: Oct-4 expression in the germline is regulated separately from epiblast expression, and this provides the first marker for the identification of totipotent cells in the embryo, and suggests that expression of Oct-4 in the Totipotent cycle is dependent on a set of factors unique to the germ line.
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Regulation of E2F1 activity by acetylation
TL;DR: It is suggested that acetylation stimulates the functions of the non‐RB bound ‘free’ form of E2F1, and it is found that the RB‐associated histone de acetylase can deacetylate E2f1.
Journal ArticleDOI
The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth.
Alexander Brehm,Alexander Brehm,Søren J. Nielsen,Eric A. Miska,Dennis J. McCance,Dennis J. McCance,Juliet L. Reid,Andrew J. Bannister,Tony Kouzarides +8 more
TL;DR: The results suggest that the binding to a histone deacetylase complex is an important parameter for the growthpromoting activity of the human papilloma virus E7 protein, and provides the first indication that viral oncoproteins control cell proliferation by targeting de acetylation pathways.