M
Marian L. Dale
Researcher at Oregon Health & Science University
Publications - 28
Citations - 309
Marian L. Dale is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Medicine & Progressive supranuclear palsy. The author has an hindex of 6, co-authored 20 publications receiving 188 citations. Previous affiliations of Marian L. Dale include Veterans Health Administration & Medical University of South Carolina.
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Pharmacological treatment in Parkinson's disease: Effects on gait
TL;DR: Paucity in the literature exists on detrimental effects of drugs used in PD that are known to worsen gait and postural stability in the elderly population, and recent work suggests that drugs aiming to enhance the acetylcholine system might improve gait stability measures.
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Open‐Label Phase 1 Futility Studies of Salsalate and Young Plasma in Progressive Supranuclear Palsy
Lawren VandeVrede,Marian L. Dale,Scott Fields,Megan Frank,Emma Hare,Hilary W. Heuer,Kellie Keith,Mary Koestler,Peter A. Ljubenkov,Dana McDermott,Noelle Ohanesian,Jennifer Richards,Julio C. Rojas,Elisabeth H. Thijssen,Elisabeth H. Thijssen,Christine M. Walsh,Ping Wang,Amy Wolf,Joseph F. Quinn,Richard M. Tsai,Adam L. Boxer +20 more
TL;DR: Progressive supranuclear palsy is a neurodegenerative disease without approved therapies, and therapeutics are often tried off‐label in the hope of slowing disease progression.
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Do cognitive measures and brain circuitry predict outcomes of exercise in Parkinson Disease: a randomized clinical trial.
Laurie A. King,Daniel S. Peterson,Daniel S. Peterson,Martina Mancini,Patricia Carlson-Kuhta,Brett W. Fling,Katrijn Smulders,John G. Nutt,Marian L. Dale,Julie H. Carter,Kerri M. Winters-Stone,Fay B. Horak,Fay B. Horak +12 more
TL;DR: The underlying hypothesis is that cognitive function and frontal lobe connections with the basal ganglia and brainstem posture/locomotor centers are responsible for postural deficits in people with Parkinson’s disease and play a role in rehabilitation efficacy.
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Associations between mobility, cognition and callosal integrity in people with parkinsonism
TL;DR: Comparisons of fiber tracts connecting prefrontal and sensorimotor cortical regions via the corpus callosum in people with two types of parkinsonism and an age-matched control group highlight the importance of prefrontal interhemispheric communication for lower extremity control in neurological patients with cognitive dysfunction.
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Impaired perception of surface tilt in progressive supranuclear palsy.
Marian L. Dale,Marian L. Dale,Fay B. Horak,Fay B. Horak,W. Geoffrey Wright,Bernadette Schoneburg,John G. Nutt,Martina Mancini +7 more
TL;DR: Difficulty perceiving backward tilt of the surface or body may account for backward falls and postural impairments in patients with PSP and observations suggest that abnormal central integration of sensory inputs for perception of body and surface orientation contributes to the pathophysiology of postural instability.