J
John G. Nutt
Researcher at Oregon Health & Science University
Publications - 342
Citations - 30041
John G. Nutt is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Parkinson's disease & Levodopa. The author has an hindex of 90, co-authored 333 publications receiving 27431 citations. Previous affiliations of John G. Nutt include University of Adelaide & Portland VA Medical Center.
Papers
More filters
Journal ArticleDOI
Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline.
Clifford W. Shults,David Oakes,Karl Kieburtz,M. Flint Beal,Richard H. Haas,Sandy Plumb,Jorge L. Juncos,John G. Nutt,Ira Shoulson,Julie H. Carter,Katie Kompoliti,Joel S. Perlmutter,Stephen G. Reich,Matthew B. Stern,Ray L. Watts,Roger Kurlan,Eric Molho,Madaline B. Harrison,Mark F. Lew +18 more
TL;DR: Coenzyme Q10 appears to slow the progressive deterioration of function in PD, but these results need to be confirmed in a larger study.
Journal ArticleDOI
Freezing of gait: Moving forward on a mysterious clinical phenomenon
TL;DR: Physiological, functional imaging, and clinical-pathological studies point to disturbances in frontal cortical regions, the basal ganglia, and the midbrain locomotor region as the probable origins of FoG.
Journal ArticleDOI
Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease.
Anthony E. Lang,Steven S. Gill,Nik K. Patel,Andres M. Lozano,John G. Nutt,Richard D. Penn,David J. Brooks,Gary Hotton,Elena Moro,Peter Heywood,Matthew Brodsky,Kim J. Burchiel,Patrick J. Kelly,Arif Dalvi,Burton L. Scott,Mark Stacy,Dennis A. Turner,V. G. Frederich Wooten,W. J. Elias,Edward R. Laws,Vijay Dhawan,A. Jon Stoessl,James Matcham,Robert J. Coffey,Michael Traub +24 more
TL;DR: This randomized controlled clinical trial was designed to confirm initial clinical benefits observed in a small, open‐label trial using intraputamenal (Ipu) infusion of recombinant human GDNF (liatermin).
Journal ArticleDOI
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease
Taye H. Hamza,Cyrus P. Zabetian,Cyrus P. Zabetian,Albert Tenesa,Alain Laederach,Jennifer S. Montimurro,Dora Yearout,Dora Yearout,Dora Yearout,Denise M. Kay,Kimberly F. Doheny,Justin Paschall,Elizabeth W. Pugh,Victoria I. Kusel,Randall V. Collura,John W. Roberts,Alida Griffith,Ali Samii,Ali Samii,William K. Scott,John G. Nutt,Stewart A. Factor,Haydeh Payami,Haydeh Payami +23 more
TL;DR: The genome-wide association study of 2,000 individuals with Parkinson's disease and unaffected controls confirmed associations with SNCA and MAPT and detected a new association with the HLA region, which was uniform across all genetic and environmental risk strata and was strong in sporadic and late-onset disease.
Journal ArticleDOI
Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1.
D.L. Browne,Stephen T. Gancher,John G. Nutt,Ewout R. Brunt,Eric A. Smith,Patricia L. Kramer,Michael Litt +6 more
TL;DR: Mutation analysis of the KCNA1 coding region in families identified four different missense point mutations present in the heterozygous state, indicating that EA/myokymia can result from mutations in this gene.