M
Mariana Franzoni Maioral
Researcher at Universidade Federal de Santa Catarina
Publications - 19
Citations - 118
Mariana Franzoni Maioral is an academic researcher from Universidade Federal de Santa Catarina. The author has contributed to research in topics: Cytotoxic T cell & Jurkat cells. The author has an hindex of 4, co-authored 17 publications receiving 82 citations.
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Journal ArticleDOI
Apoptotic events induced by synthetic naphthylchalcones in human acute leukemia cell lines
Mariana Franzoni Maioral,Pâmela Cristina Gaspar,Gabriela Regina Rosa Souza,Alessandra Mascarello,Louise Domeneghini Chiaradia,Marley Aparecida Licínio,Ana Carolina Rabello de Moraes,Rosendo A. Yunes,Ricardo José Nunes,Maria Cláudia Santos-Silva +9 more
TL;DR: The results suggest that chalcone A1 has potential as a new lead compound for cancer therapy and was chosen for further analysis in six human acute leukemia cells and in a human colon adenocarcinoma cell line.
Journal ArticleDOI
Synthesis of novel pyrazoline derivatives and the evaluation of death mechanisms involved in their antileukemic activity.
Natália Marceli Stefanes,Jessica Toigo,Mariana Franzoni Maioral,Amanda Virtuoso Jacques,Louise Domeneghini Chiaradia-Delatorre,Daiane Mari Perondi,Amanda Abdalla Biasi Ribeiro,Alisson Bigolin,Iris Mattos Santos Pirath,Bruna Fischer Duarte,Ricardo José Nunes,Maria Cláudia Santos-Silva +11 more
TL;DR: Five new pyrazolines showed adequate physicochemical properties for a good oral bioavailability and were found to be highly selective for leukemic cells when compared to non-neoplastic cells and did not cause lysis on human red blood cells.
Journal ArticleDOI
Cytotoxic effect of a novel naphthylchalcone against multiple cancer cells focusing on hematologic malignancies.
Mariana Franzoni Maioral,Camila do Nascimento Bodack,Natália Marceli Stefanes,Alisson Bigolin,Alessandra Mascarello,Louise Domeneghini Chiaradia-Delatorre,Rosendo A. Yunes,Ricardo José Nunes,Maria Cláudia Santos-Silva +8 more
TL;DR: The results suggest that A23 is an interesting compound with strong and selective anti-tumor activity and seems to have a synergic effect with the chemotherapy drugs cytarabine and vincristine.
Journal ArticleDOI
Oral Delivery of a High Quercetin Payload Nanosized Emulsion: In Vitro and In Vivo Activity Against B16-F10 Melanoma.
Cristiana Lima Dora,Luis Felipe Costa Silva,Letícia Mazzarino,Jarbas Mota Siqueira,Daniel Fernandes,Letícia Kramer Pacheco,Mariana Franzoni Maioral,Maria Cláudia Santos-Silva,Ana Luiza Muccillo Baischl,Jamil Assreuy,Elenara Lemos-Senna +10 more
TL;DR: Results suggest that an improvement in the oral bioavailability of quercetin occurred when this compound was dissolved in the oily phase of a nanosized emulsion, indicating that it might have a potential application in the treatment of melanoma.
Journal ArticleDOI
MICONIDINE acetate, a new selective and cytotoxic compound with synergic potential, induces cell cycle arrest and apoptosis in leukemia cells.
Mariana Franzoni Maioral,Natália Marceli Stefanes,Alisson Bigolin,Gabriele Andressa Zatelli,Ana Cláudia Philippus,Miriam Falkenberg,Maria Cláudia Santos-Silva +6 more
TL;DR: It is indicated that MA may be a new agent for AL and its potential as a new source of anticancer drugs is highlighted, as well as the cytotoxic effect of chemotherapeutics cytarabine and vincristine.