Showing papers in "Biochimie in 2017"

TL;DR: In addition to helping to correct dyslipidemia, PPARα agonists may hold promise as a therapy for patients with cholestatic liver diseases, non-alcoholic fatty liver disease, and/or type 2 diabetes.

TL;DR: A critical role of the host cell protease TMPR SS2 in influenza virus and coronavirus infections is outlined and an antiviral therapeutic strategy targeting TMPRSS2 is highlighted.

TL;DR: The current review summarizes the latest findings regarding structure-function relationship of Apaf-1 as well as its modifiers and describes the mechanism of oligomerization and caspase-9 activation in the apoptosome.

TL;DR: Current evidence from preclinical and clinical studies investigating the therapeutic potential of PPAR ligands for the treatment of nonalcoholic fatty liver disease is reviewed.

TL;DR: Prebiotics, probiotics, polyphenols, peroxisome proliferator-activated receptor-γ agonists and exercise have been shown to reverse HFD-induced intestinal phenotype and to attenuate the severity of obesity and its associated metabolic complications.

TL;DR: To restrict investigations to examine adipose tissue depots where only a limited part of the adaptation process occurs (i.e. the brite/beige tissues) and to use initial conditions different from the thermoneutrality normally experienced by adult humans may seriously hamper the identification of therapeutically valid browning agents.

TL;DR: Both CD36/SR-B2 and the PPARs have been implicated in the derangements in fatty acid and lipid metabolism occurring with the development of pathophysiological conditions, and have been suggested as targets for metabolic intervention.

TL;DR: The properties of ruminant trans 18:1, when compared to industrial trans 18-1, CLA and CLnA on human health from meta-analyses of intervention studies are described and the underlying mechanisms are explored.

TL;DR: The bright antiatherogenic activity of the PON cluster makes it a promising target for the development of new therapeutic strategies, which include antioxidant activity,Anti-inflammatory action, preserving HDL function, stimulation of cholesterol efflux, anti-apoptosis, anti -thrombosis, and anti-adhesion.

TL;DR: Exosomes play a major role in HEV egress but HEV infection does not modify the characteristics of the bulk of exosomes produced by infected cells, which could lead to the wide circulation of HEV in its host.

TL;DR: In conclusion, UCP1 has retained all of the key features of mitochondrial carriers, indicating that it operates by a conventional carrier-like mechanism.

TL;DR: The present text summarizes what was my contribution, starting in 1975, to the research on the uncoupling protein 1 (UCP1), the mitochondrial uncoupler of brown adipocytes, which has opened new avenues for studying energy expenditure in relation to overweight, obesity and related pathologies.

TL;DR: Bacterial type II fatty acid synthesis (FASII) is a target for novel antibiotic development and attempts have been made to estimate the natural prevalence of these mutants, but culture-independent metagenomic methods would provide a better estimate.

TL;DR: Current knowledge on the metabolic pathways involved in generation of DHA metabolites is summarized, and it is likely that novel bioactive derivatives will be identified in the future.

TL;DR: Investigations in the mid-late 1970s established the uncoupling of oxidative phosphorylation through a proton conductance pathway across the mitochondrial inner membrane as the mechanism for heat production in BAT, this being regulated by UCP1 which was first discovered as a cold-inducible protein.

TL;DR: In this paper, mutations in genes encoding aconitase, isocitrate dehydrogenase, succinate dehydrogenases, fumarate hydratase, and citrate synthase are noted in many cancers.

TL;DR: The unique properties of the UCP1 promoter region have been exploited to develop brown adipose tissue-specific gene delivery tools for experimental purposes and it has been reported that specific aspects of obesity and associated metabolic diseases are associated with human population variability at this site.

TL;DR: This review aims to summarize quantitative findings regarding stabilization role of CL in IMPs reported up to now.

TL;DR: The patch-clamp technique was successfully applied to the inner mitochondrial membrane of brown fat to directly characterize the H+ currents carried by UCP1, and a new model of U CP1 operation was proposed, which effectively operates as an H+ uniport in the presence of long-chain FA, endogenous activators of brownfat thermogenesis.

TL;DR: Results clearly showed that, morin by acting on Hippo/Yap and TGF-β1/Smad pathways, ameliorated experimental liver fibrosis, indicating that morin has potential for effective treatment of Liver fibrosis.

TL;DR: The current study suggests that DHODH inhibitors are most effective in cells that express high levels ofDHODH enzyme, and the inhibition of cell proliferation by these inhibitors appears to be accompanied by ROS production as well as ATP depletion.

TL;DR: It is suggested that, similar to classical G4s, imperfect G 4s could be considered as potential regulatory elements, pathology biomarkers and therapeutic targets, reflecting the enhanced sequential diversity of these motifs.

TL;DR: Up-to-date structural knowledge about amyloid-β peptides is reviewed, focusing on data acquired using solution and solid state NMR techniques, to discuss implications from these structural studies on the mechanisms of aggregation and neurotoxicity.

TL;DR: The impact, functional consequences and potential mechanism of action of macronutrients, micronutrient and bioactive compounds impinging on UCP1 expression/activity is discussed, as well as emerging links between human genetic variation and differential responses to potential thermogenic food ingredients.

TL;DR: This review describes recent evidence about the dual interaction of mycobacteria with host LDs and membrane phospholipids and integrates them in a broader view of the underlying cellular processes manipulated by various intracellular pathogens to gain access to host lipids.

TL;DR: The Dox-loaded CoFe2O4@DMSA nanoparticles can be used as a potential therapeutic agent in cancer therapy by combining the thermo-chemotherapy techniques.

TL;DR: This review made an attempt to cover the available knowledge about synthesis and molecular function of oxylipins known to modulate adipogenesis, adipocyte function and phenotype conversion, with a focus on their interaction with peroxisome proliferator-activated nuclear receptor family.

TL;DR: The multifaceted roles of PPARβ/δ in skeletal muscle physiology are reviewed, which are now becoming more recognized in fatty acid metabolism, energy expenditure, and tissue repair.

TL;DR: PPAR-alpha activation reduced BM and treated insulin resistance (IR) and NAFLD by increasing the number of mitochondria and reducing hepatic gluconeogenesis and de novo lipogenesis protein and gene expressions in a murine obesity model.

TL;DR: The most recent studies on the role of STATs, with focus on STAT3, in oncogenesis, and the promising effects of some polyphenols on STAT expression are assessed, with a focus on their ability to target specific cell-signalling pathways.