M
Marie Bénéteau
Researcher at French Institute of Health and Medical Research
Publications - 13
Citations - 889
Marie Bénéteau is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Apoptosis & Glycolysis Inhibition. The author has an hindex of 11, co-authored 13 publications receiving 793 citations. Previous affiliations of Marie Bénéteau include University of Nice Sophia Antipolis & Université Bordeaux Segalen.
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Journal ArticleDOI
Mitochondrial control of caspase-dependent and -independent cell death.
Ludivine A. Pradelli,Ludivine A. Pradelli,Marie Bénéteau,Marie Bénéteau,Jean-Ehrland Ricci,Jean-Ehrland Ricci +5 more
TL;DR: The mechanism underlying the mitochondrial control of apoptosis and caspase-independent cell death is discussed and recent findings are highlighted.
Journal ArticleDOI
Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation.
Pradelli La,Marie Bénéteau,Marie Bénéteau,C Chauvin,C Chauvin,Marie A. Jacquin,Marie A. Jacquin,Sandrine Marchetti,Sandrine Marchetti,Cristina Muñoz-Pinedo,Patrick Auberger,Patrick Auberger,Mario Pende,Mario Pende,Jean-Ehrland Ricci,Jean-Ehrland Ricci,Jean-Ehrland Ricci +16 more
TL;DR: The results show a novel mechanism for the sensitization to DR-induced apoptosis linking glucose metabolism to Mcl-1 downexpression, and provide a rationale for the combined use of DR ligands with AMPK activators or mTOR inhibitors in the treatment of human cancers.
Journal ArticleDOI
Refractory epilepsy and mitochondrial dysfunction due to GM3 synthase deficiency.
Konstantina Fragaki,Samira Ait-El-Mkadem,Annabelle Chaussenot,Catherine Gire,Raymond Mengual,Laurent Bonesso,Marie Bénéteau,Jean-Ehrland Ricci,Valérie Desquiret-Dumas,Vincent Procaccio,Agnès Rötig,Véronique Paquis-Flucklinger +11 more
TL;DR: It is shown for the first time that GM3 synthase deficiency, responsible for early-onset epilepsy syndrome, leads to a secondary RC dysfunction, which highlights the role of secondary mitochondrial disorders that can interfere with the diagnosis and the evolution of other metabolic diseases.
Journal ArticleDOI
Combination of glycolysis inhibition with chemotherapy results in an antitumor immune response
Marie Bénéteau,Barbara Zunino,Barbara Zunino,Marie A. Jacquin,Ophélie Meynet,Johanna Chiche,Ludivine A. Pradelli,Sandrine Marchetti,Sandrine Marchetti,Aurore Cornille,Michel Carles,Jean-Ehrland Ricci,Jean-Ehrland Ricci +12 more
TL;DR: It is identified that the targeting of glycolysis can convert conventional tolerogenic cancer cell death stimuli into immunogenic ones, thus creating new strategies for immunogenic chemotherapy.
Journal ArticleDOI
GAPDH binds to active Akt, leading to Bcl-xL increase and escape from caspase-independent cell death
Jacquin Ma,Johanna Chiche,Johanna Chiche,Barbara Zunino,Marie Bénéteau,Marie Bénéteau,Ophélie Meynet,Ophélie Meynet,Ludivine A. Pradelli,Ludivine A. Pradelli,Sandrine Marchetti,Sandrine Marchetti,Cornille A,Cornille A,Michel Carles,Michel Carles,Jean-Ehrland Ricci +16 more
TL;DR: This work suggests that GAPDH overexpression could induce Bcl-xL overeexpression and protect cells from CICD-induced chemotherapy through preservation of intact mitochondria that may facilitate tumor survival and chemotherapeutic resistance.