M
Marieke Aarts
Researcher at Institute of Cancer Research
Publications - 17
Citations - 807
Marieke Aarts is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Gene targeting & Stem cell. The author has an hindex of 13, co-authored 16 publications receiving 724 citations. Previous affiliations of Marieke Aarts include Erasmus University Rotterdam & The Breast Cancer Research Foundation.
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Journal ArticleDOI
Forced Mitotic Entry of S-Phase Cells as a Therapeutic Strategy Induced by Inhibition of WEE1
Marieke Aarts,Rachel Sharpe,Isaac Garcia-Murillas,Heidrun Gevensleben,Melissa S. Hurd,Stuart D. Shumway,Carlo Toniatti,Alan Ashworth,Nicholas C. Turner +8 more
TL;DR: It is shown that p53/p21 inactivation combined with high expression of mitotic cyclins and EZH2 predispose to mitotic entry during S-phase with cells reliant on WEE1 to prevent premature cyclin-dependent kinase (CDK)1 activation.
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CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours.
Sara Costa-Cabral,Rachel Brough,Asha Konde,Marieke Aarts,James Campbell,Eliana Marinari,Jenna L. Riffell,Alberto Bardelli,Christopher Torrance,Christopher J. Lord,Alan Ashworth +10 more
TL;DR: A novel, robust, KRAS synthetic lethal interaction with the cyclin dependent kinase, CDK1 is described and validated in a genetically diverse panel of 26 colorectal and pancreatic tumour cell models, suggesting that the KRAS/CDK1 interaction is a robust synthetic lethal effect worthy of further investigation.
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Tumour selective targeting of cell cycle kinases for cancer treatment.
TL;DR: The strategies used to exploit the dysregulated cell cycle are reviewed, both through targeting kinases required for cell cycle progression, and checkpoint kinases to inappropriately force cells through the cell cycle.
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Generation of a mouse mutant by oligonucleotide-mediated gene modification in ES cells
TL;DR: A simple and rapid procedure for the generation of mouse mutants using transient down regulation of the central MMR protein MSH2 by RNA interference is reported, demonstrating that under this condition, unmodified single-stranded DNA oligonucleotides can be used to substitute single or several nucleotides.
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Progress and prospects: oligonucleotide-directed gene modification in mouse embryonic stem cells: a route to therapeutic application.
Marieke Aarts,H te Riele +1 more
TL;DR: The significant progress that has been made over the last 5 years in unraveling the mechanisms and reaction parameters underlying ssODN-mediated gene targeting in murine embryonic stem cells and the impact of the DNA mismatch repair (MMR) system on the targeting process is discussed.