Sandra S. de Vries

TL;DR: The H3K9 methyltransferase G9a is identified as a regulator of NL contacts and contact of individual LADs with the NL is linked to transcriptional repression and H 3K9 dimethylation in single cells.

TL;DR: The consistency of NL contacts is inversely linked to gene activity in single cells and correlates positively with the heterochromatic histone modification H3K9me3, which highlights fundamental principles of single-cell chromatin organization.

TL;DR: QTL analysis of 222 F2 mice revealed four new loci that influence susceptibility to lung cancer (Sluc genes), indicating that interactions between tumour susceptibility genes are a common phenomenon which complicates their mapping.

TL;DR: The findings suggest that Msh4/5 heterodimers contribute to CSR and support a model whereby Msh 4/5 promotes the resolution of DNA breaks with low or no terminal microhomology by a classical nonhomologous end-joining mechanism while possibly suppressing an alternative microHomology-mediated pathway.

TL;DR: High-resolution maps of genomic interactions with the nuclear lamina in mouse pre-implantation embryos reveal that nuclear organization is not inherited from the maternal germline but is instead established de novo shortly after fertilization, suggesting a step-wise assembly model whereby early LAD formation precedes consolidation of topologically associating domains.