https://www.repositorio.ufop.br/bitstream/123456789/805/6/ARTIGO_TrioxygenatedNaturallyOccurring.pdf

Tetraoxygenated naturally occurring xanthones

Antimicrobial activities of methanol extract and compounds from stem bark of Vismia rubescens.

Ethnobotany : Application of Medicinal Plants

Laurentixanthones A and B, antimicrobial xanthones from Vismia laurentii

Snakebites are a serious problem in public health due to their high morbimortality. Most of snake venoms produce intense local tissue damage, which could lead to temporary or permanent disability in victims. The available specific treatment is the antivenom serum therapy, whose effectiveness is reduced against these effects. Thus, the search for complementary alternatives for snakebite treatment is relevant. There are several reports of the popular use of medicinal plants against snakebites worldwide. In recent years, many studies have been published giving pharmacological evidence of benefits of several vegetal species against local effects induced by a broad range of snake venoms, including inhibitory potential against hyaluronidase, phospholipase, proteolytic, hemorrhagic, myotoxic, and edematogenic activities. In this context, this review aimed to provide an updated overview of medicinal plants used popularly as antiophidic agents and discuss the main species with pharmacological studies supporting the uses, with emphasis on plants inhibiting local effects of snake envenomation. The present review provides an updated scenario and insights into future research aiming at validation of medicinal plants as antiophidic agents and strengthens the potentiality of ethnopharmacology as a tool for design of potent inhibitors and/or development of herbal medicines against venom toxins, especially local tissue damage.

/pdf/medicinal-plants-for-the-treatment-of-local-tissue-damage-30ym1llcf6.pdf

Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence.

Most of the snakebite incidents in the Amazon region involve Bothrops atrox, whose venom presents the most potent edematogenic and necrotic activities in the genus. This work describes the studies of isolation of the chemical constituents and antiedematogenic activity of the species Peltodon radicans (Lamiaceae), which is used in the treatment of snakebites and scorpion stings in the region. The extracts presented aliphatic hydrocarbons, 3b-OH,b-amirin (1), 3b-OH,a-amirin (2), b-sitosterol (3), stigmasterol (4), ursolic acid (5), 2a,3b,19a-trihydroxy-urs-12-en-28-oic acid (tormentic acid, 6), methyl 3b-hydroxy,28-methyl-ursolate (7), sitosterol-3-O-b-D-glucopyranoside (8), and stigmasterol-3-O-b-D-glucopyranoside (9). The flower extracts presented the higher antiedematogenic activity. This is the first report on the study of the flowers, stem, and roots of this plant.

/pdf/constituintes-quimicos-e-atividade-antiedematogenica-de-pgufyptcwc.pdf

Constituintes químicos e atividade antiedematogênica de Peltodon radicans (Lamiaceae)

A new xanthone,1,4,8-trihydroxyxanthone (1,4,8-trihydroxy-9H-xanthen-9-one), was isolated from the roots of Vismia latifolia (Guttiferae). Four other known xanthones were isolated: 1,5-dihydroxy-8-methoxyxanthone, 1,7-dihydroxyxanthone, 1,6-dihydroxy-7-methoxyxanthone and 1,3,5,6-tetrahydroxyxanthone. The last two compounds were isolated for the first time from a Vismia species. The structures were established by UV, IR, MS, 1D and 2D NMR spectroscopic techniques.

/pdf/xanthones-from-vismia-latifolia-4jve5kl6ag.pdf

Xanthones from Vismia latifolia

Tres cumarinas, 5-metoxipsoraleno, xantiletina e (-)-marmesina, foram isoladas no extrato etanolico do cerne da planta amazonica Brosimum potabile. Suas estruturas foram determinadas a partir das analises por RMN e por comparacao com dados espectroscopicos da literatura. As analises das fracoes hexânicas por CG/EM sugeriram a presenca de (1-metilpentil)-benzeno; α,α-dimetil-4-(1-metiletil)-benzenometanol; 1-metil-3,5-bis(1-metiletil)-benzeno; urs-12-eno; cola-5,22-dien-3β-ol; colesta-4,6-dien-3β-ol; (9Z)-octadecenoato de sitosterila; colesta-5,22-dien-3β-ol; colesta-4,6,22-trien-3-ona e colesta-4,22-dien-3-ona. Dados de RMN de outras fracoes hexânicas indicaram a presenca de 3β-acetoxi-lup-12,20(29)-dieno; 3β-acetoxi-olean-12-eno; 3β-acetoxi-urs-12-eno e adian-5-eno. Todos esses compostos foram identificados pela primeira vez em B. potabile.

/pdf/chemical-constituents-from-the-stem-of-brosimum-potabile-18n0wucze0.pdf

Chemical constituents from the stem of Brosimum potabile (Moraceae)

Clathraxanthone, a 1,2,7-trioxygenated xanthone from Haploclathra paniculata

O objetivo deste trabalho foi verificar o efeito antioxidante de derivados flavonoidicos da quercetina, naringenina, morina, e rutina, isolados da cultivar de soja UFV-5. Apos acetilacao com anidrido acetico e piridina, e metilacao com diazometano, esses compostos foram analisados para determinacao de acao antioxidante por meio dos indices de acidez, iodo e peroxido e pela reacao-de-Kreiss. Os melhores resultados foram obtidos com a naringenina metilada, naringenina acetilada, quercetina metilada e quercetina acetilada.

/pdf/acao-antioxidante-de-flavonoides-modificados-1jk0n93usl.pdf

Marilda Conceição da Silva

Papers

Constituintes químicos e atividade antiedematogênica de Peltodon radicans (Lamiaceae)

Xanthones from Vismia latifolia

Chemical constituents from the stem of Brosimum potabile (Moraceae)

Clathraxanthone, a 1,2,7-trioxygenated xanthone from Haploclathra paniculata

Ação antioxidante de flavonóides modificados