Occurrence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates.

Properties of lactic acid based polymers and their correlation with composition

Thermal stability and flame retardancy of polyurethanes

Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

Medical devices and applications of polyhydroxyalkanoate polymers

Glycosylation is a common post-translational modification to cell surface and extracellular matrix (ECM) proteins as well as to lipids. As a result, cells carry a dense coat of carbohydrates on their surfaces that mediates a wide variety of cell-cell and cell-matrix interactions that are crucial to development and function. Because of the historical difficulties with the analysis of complex carbohydrate structures, a detailed understanding of their roles in biology has been slow to develop. Just as mass spectrometry has proven to be the core technology behind proteomics, it stands to play a similar role in the study of functional implications of carbohydrate expression, known as glycomics. This review summarizes the state of knowledge for the mass spectrometric analysis of oligosaccharides with regard to neutral, sialylated, and sulfated compound classes. Mass spectrometric techniques for the ionization and fragmentation of oligosaccharides are discussed so as to give the reader the background to make informed decisions to solve structure-activity relations in glycomics.

Mass spectrometry of oligosaccharides.

Determination of linkage position and identification of the reducing end in linear oligosaccharides by negative ion fast atom bombardment mass spectrometry

Primary thermal decomposition processes in aliphatic polyesters investigated by chemical ionization mass spectrometry

Primary thermal decomposition processes in aliphatic polyamides

Optimisation de la methanolyse du copolymere et du poly(hydroxy butyrate) pour obtenir des oligomeres de masse moleculaire inferieure a la limite de detection (2000 daltons) Spectres FAB constitues d'ions pseudomoleculaires MH + et MNa + , permettant l'identification des produits de methanolyse, la determination de la composition du copolymere et la distribution des sequences de monomeres

Sequencing bacterial poly(.beta.-hydroxybutyrate-co-.beta.-hydroxyvalerate) by partial methanolysis, HPLC fractionation, and fast-atom-bombardment mass spectrometry analysis

Mario Giuffrida

Papers

Determination of linkage position and identification of the reducing end in linear oligosaccharides by negative ion fast atom bombardment mass spectrometry

Primary thermal decomposition processes in aliphatic polyesters investigated by chemical ionization mass spectrometry

Primary thermal decomposition processes in aliphatic polyamides

Sequencing bacterial poly(.beta.-hydroxybutyrate-co-.beta.-hydroxyvalerate) by partial methanolysis, HPLC fractionation, and fast-atom-bombardment mass spectrometry analysis

Mechanism of thermal decomposition of nylon 66