M
Mario Mörl
Researcher at Leipzig University
Publications - 91
Citations - 4165
Mario Mörl is an academic researcher from Leipzig University. The author has contributed to research in topics: Transfer RNA & tRNA nucleotidyltransferase. The author has an hindex of 34, co-authored 86 publications receiving 3692 citations. Previous affiliations of Mario Mörl include Technical University of Berlin & Ludwig Maximilian University of Munich.
Papers
More filters
Journal ArticleDOI
tRNAdb 2009: compilation of tRNA sequences and tRNA genes
TL;DR: The tRNAdb database as discussed by the authors contains more than 12 000 tRNA genes, classified into families according to amino acid specificity, and the implementation of the NCBI taxonomy tree facilitates phylogeny-related queries.
Journal ArticleDOI
tRNA Modifications: Impact on Structure and Thermal Adaptation.
TL;DR: It was shown that tRNA modifications are important for temperature adaptation in thermophilic as well as psychrophilic organisms, as they modulate rigidity and flexibility of the transcripts, respectively.
Journal ArticleDOI
Probing the SELEX Process with Next-Generation Sequencing
Tatjana Schütze,Barbara Wilhelm,Nicole Greiner,Hannsjörg Braun,Franziska Peter,Mario Mörl,Volker A. Erdmann,Hans Lehrach,Zoltán Konthur,Marcus Menger,Peter F. Arndt,Jörn Glökler +11 more
TL;DR: A new selection scheme is suggested that avoids a high number of iterative selection rounds while reducing time, PCR bias, and artifacts and high affinity aptamers can be readily identified simply by copy number enrichment in the first selection rounds.
Journal ArticleDOI
De novo design of a synthetic riboswitch that regulates transcription termination
TL;DR: Several of the designed constructs show ligand-dependent control of gene expression in Escherichia coli, demonstrating that it is possible to engineer riboswitches not only for translational but also for transcriptional regulation.
Journal ArticleDOI
Mitochondrial tRNA 3' end metabolism and human disease
TL;DR: Here, the effectiveness and reliability of evidence obtained from reactions with in vitro transcripts that pathogenesis-associated mutant mitochondrial tRNAs can lead to deficiencies in tRNA 3' end metabolism (3' end cleavage, CCA addition and aminoacylation) are critically reviewed toward an understanding of molecular mechanisms underlying human tRNA disorders.