M
Mario Thevis
Researcher at German Sport University Cologne
Publications - 512
Citations - 13310
Mario Thevis is an academic researcher from German Sport University Cologne. The author has contributed to research in topics: Mass spectrometry & Metabolite. The author has an hindex of 53, co-authored 476 publications receiving 11753 citations. Previous affiliations of Mario Thevis include Saarland University & University of California, Los Angeles.
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Journal ArticleDOI
Evaluation of the Biological Activity of a Growth Hormone (GH) Mutant (R77C) and Its Impact on GH Responsiveness and Stature
Vibor Petkovic,Amélie Besson,Mario Thevis,Didier Lochmatter,Andrée Eblé,Christa E. Flück,Primus E. Mullis +6 more
TL;DR: Reduced GH receptor/GH-binding protein expression might be a possible cause for the partial GH insensitivity with delay in growth and pubertal development found in patients.
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Proteolysis and autolysis of proteases and the detection of degradation products in doping control.
TL;DR: The present approach was developed to identify degradation products directly from proteases with exogenous origin in urine samples by means of SDS-PAGE and capillary liquid chromatography-Orbitrap (tandem) mass spectrometry.
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The fungus Cunninghamella elegans can produce human and equine metabolites of selective androgen receptor modulators (SARMs).
TL;DR: The study showed that the fungus produced relevant metabolites of the SARMs and thus can be used to mimic mammalian metabolism and has the potential to be used for future production of reference material.
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Mass spectrometry of steroid glucuronide conjugates. II—Electron impact fragmentation of 3-keto-4-en- and 3-keto-5α-steroid-17-O-β glucuronides and 5α-steroid-3α,17β-diol 3- and 17-glucuronides
TL;DR: The steroid glucuronide conjugates of 16,16,17-d(3)-testosterone, epitestosterone, nandrolone (19-nortestosterone), 16, 16, 17-d (3)-nortestsosterone, methyltest testosterone, metenolone, mesterolone and 5alpha-androstane-3alpha,17beta-diol were synthesized by means of the Koenigs-Knorr reaction.
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Recent improvements in sports drug testing concerning the initial testing for peptidic drugs (< 2 kDa) – sample preparation, mass spectrometric detection, and data review
TL;DR: The combination of well-established strategies for the determination of peptides, such as two-dimensional liquid chromatography, dimethyl sulfoxide-assisted electrospray ionization, high resolution mass spectrometric detection and a tailored reporter template, provides a high-throughput initial testing assay for lower molecular mass peptidic and peptide-related analytes.