Marissa Danielle Acciani

TL;DR: The data suggest these residues are critical for GP2 function in LASV entry, and seven GP2 mutants that were cleaved efficiently but were unable to effectively transduce cells are identified.

TL;DR: This study produced pseudotyped VSV particles with multiple modifications to S, including truncation, mutation, and tagging strategies, to determine which modifications of the S protein optimize cell surface expression, incorporation into pseudotypesed particles, and pseudoparticle entry.

TL;DR: The results highlight a region within the Lassa virus GP1 protein that interacts with the cellular receptor alpha-dystroglycan, which may be used for future development of new LassA virus antivirals.

TL;DR: The data indicate that rVSV particles with glycoproteins that require more post-internalization priming typically demonstrate delayed entry in comparison to VSV G, and a system to evaluate viral cell surface receptor preferences, monitor fusion, and elucidate endocytosis mechanisms is employed.

TL;DR: In this paper, two scramblases, transmembrane protein 16F (TM16F) and Xk-related protein 8 (XKR8), were investigated as mediators of cellular and viral envelope surface PS levels during the replication of recombinant vesicular stomatitis virus containing its native glycoprotein (rVSV/G) or the EBOV glycopprotein (rVV/EBOV-GP).