M
Mark B. Pepys
Researcher at University College London
Publications - 309
Citations - 49754
Mark B. Pepys is an academic researcher from University College London. The author has contributed to research in topics: Serum amyloid P component & Amyloidosis. The author has an hindex of 94, co-authored 309 publications receiving 47486 citations. Previous affiliations of Mark B. Pepys include Manchester Royal Infirmary & Hammersmith Hospital.
Papers
More filters
Journal ArticleDOI
C-reactive protein: a critical update
TL;DR: Information is provided about CRP as a protein and an acute-phase reactant, and a knowledge-based framework for interpretation and analysis of clinical observations of CRP in relation to cardiovascular and other diseases, that identifies it as a possible therapeutic target.
Journal ArticleDOI
C-Reactive Protein and Other Circulating Markers of Inflammation in the Prediction of Coronary Heart Disease
John Danesh,J. G. Wheeler,Gideon M. Hirschfield,Shinichi Eda,Gudny Eiriksdottir,Ann Rumley,Gordon D.O. Lowe,Mark B. Pepys,Vilmundur Gudnason +8 more
TL;DR: The long-term stability of C-reactive protein values was similar to that of both blood pressure and total serum cholesterol, and recommendations regarding its use in predicting the likelihood of coronary heart disease may need to be reviewed.
Journal ArticleDOI
The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina
Giovanna Liuzzo,Luigi M. Biasucci,Gallimore,R. Grillo,A. G. Rebuzzi,Mark B. Pepys,Attilio Maseri +6 more
TL;DR: Elevation of the sensitive acute-phase proteins C-reactive protein and serum amyloid A protein at the time of hospital admission predicts a poor outcome in patients with unstable angina and may reflect an important inflammatory component in the pathogenesis of this condition.
Journal ArticleDOI
C-Reactive Protein, a Sensitive Marker of Inflammation, Predicts Future Risk of Coronary Heart Disease in Initially Healthy Middle-Aged Men Results From the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992
Wolfgang Koenig,M. Sund,Margit Fröhlich,Hans-Günther Fischer,Hannelore Löwel,Angela Döring,Winston L. Hutchinson,Mark B. Pepys +7 more
TL;DR: These results confirm the prognostic relevance of CRP, a sensitive systemic marker of inflammation, to the risk of CHD in a large, randomly selected cohort of initially healthy middle-aged men and suggest that low-grade inflammation is involved in pathogenesis of atherosclerosis, especially its thrombo-occlusive complications.
Journal ArticleDOI
C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis.
Stephen Kaptoge,E Di Angelantonio,Gordon D.O. Lowe,Mark B. Pepys,Simon G. Thompson,Rory Collins,John Danesh +6 more
TL;DR: CRP concentration has continuous associations with the risk of coronary heart disease, ischaemic stroke, vascular mortality, and death from several cancers and lung disease that are each of broadly similar size.