M
Mark B. Pepys
Researcher at University College London
Publications - 309
Citations - 49754
Mark B. Pepys is an academic researcher from University College London. The author has contributed to research in topics: Serum amyloid P component & Amyloidosis. The author has an hindex of 94, co-authored 309 publications receiving 47486 citations. Previous affiliations of Mark B. Pepys include Manchester Royal Infirmary & Hammersmith Hospital.
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Science and serendipity
TL;DR: Good science demands independent replication of new ideas and results and abandonment of accepted theories in light of more reliable evidence, and progress of good science also often requires serendipity, 'making discoveries by accident and sagacity of things not sought'.
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Tissue amyloid P component in normal human dermis is non-covalently associated with elastic fiber microfibrils.
TL;DR: The findings that denaturing agents alone extracted most of the TAP from normal human dermis strongly suggest that the great majority of the dermal TAP is non-covalently bound to elastic fiber microfibrils.
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A pentameric form of human serum amyloid P component. Crystallization, X-ray diffraction and neutron scattering studies.
S.P. Wood,Glaucius Oliva,B.P. O'Hara,Helen E. White,Tom L. Blundell,Stephen J. Perkins,I. Sardharwalla,Mark B. Pepys +7 more
TL;DR: Density considerations supported by neutron scattering and gel filtration experiments indicate that the human serum amyloid P component crystallized is pentameric.
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Complement independence of stimulation of mouse splenic B lymphocytes by mitogens.
TL;DR: Observations as well as extensive studies on antigens13 with different physical properties suggest that the size, multivalency and manner of presentation of the ligand determine whether T or B cells will be stimulated.
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Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C‐reactive protein, for clinical use
Mark B. Pepys,J. Ruth Gallimore,Joanne Lloyd,Zhanhong Li,David Graham,Graham W. Taylor,Stephan Ellmerich,Palma Mangione,Palma Mangione,Glenys A. Tennent,Winston L. Hutchinson,David J. Millar,Gary Bennett,John More,David Evans,Yogesh Mistry,Stephen Poole,Philip N. Hawkins +17 more
TL;DR: It is demonstrated that, contrary to reports using recombinant proteins and less well characterized preparations, neither CRP nor SAP stimulate the release by human peripheral blood mononuclear cells in vitro of any TNFα, IL‐6 or IL‐8, nor does SAP cause release of IL‐1β or IL-10.