M
Mark Budde
Researcher at Fred Hutchinson Cancer Research Center
Publications - 6
Citations - 261
Mark Budde is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Wax & Caenorhabditis elegans. The author has an hindex of 5, co-authored 6 publications receiving 227 citations. Previous affiliations of Mark Budde include University of Washington.
Papers
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Journal ArticleDOI
Fatty Aldehydes in Cyanobacteria Are a Metabolically Flexible Precursor for a Diversity of Biofuel Products
Brett K. Kaiser,Michael Carleton,Jason W. Hickman,Cameron Miller,David W. Lawson,Mark Budde,Paul Warrener,Angel Paredes,Srinivas Mullapudi,Patricia Navarro,Frederick R. Cross,James M. Roberts,James M. Roberts +12 more
TL;DR: A cyanobacteria class-3 aldehyde-dehydrogenase, AldE, was discovered that was necessary and sufficient to instead oxidize fatty aldehydes precursors into fatty acids, which may allow biofuel production without transgenesis.
Journal ArticleDOI
The Response of Caenorhabditis elegans to Hydrogen Sulfide and Hydrogen Cyanide
TL;DR: It is shown that growing worms in the presence of H2S is sufficient to confer resistance to Pseudomonas fast paralytic killing, and the results suggest the hypoxia-independent hif-1 response in C. elegans evolved to respond to the naturally occurring small molecules H 2S and HCN.
Journal ArticleDOI
Glycogen synthesis is a required component of the nitrogen stress response in Synechococcus elongatus PCC 7942
Jason W. Hickman,Kimberly Marie Kotovic,Cameron Miller,Paul Warrener,Brett K. Kaiser,Tracey Jurista,Mark Budde,Frederick R. Cross,James M. Roberts,Michael Carleton +9 more
TL;DR: It is discovered that when glycogen synthesis was abolished, by deletion of the gene for glucose-1-phosphate adenylyl transferase (glgC), Synechococcus elongatus PCC 7942 was unable to degrade its phycobilisomes in response to nitrogen stress, and glgC null cells exhibited a non-bleaching phenotype in responseto sulfur and phosphate stress.
Journal ArticleDOI
HIF-1 and SKN-1 coordinate the transcriptional response to hydrogen sulfide in Caenorhabditis elegans.
TL;DR: A model in which HIF-1 and SKN-1 coordinate a broad transcriptional response to H2S that culminates in a global reorganization of protein homeostasis networks is suggested.
Patent
Modified photosynthetic microorganisms for continuous production of carbon-containing compounds
Jason W. Hickman,James M. Roberts,Kimberly Marie Kotovic,Cameron Miller,Michael Carleton,Mark Budde,Frederick R. Cross,Brett K. Kaiser,Paul Warrener +8 more
TL;DR: In this paper, a continuous production system for producing carbon-containing compounds, comprising a genetically modified photosynthetic microorganism such as a Cyanobacterium, that contains one or more mutations or deletions in a glycogen biosynthesis or storage pathway, is described.