Paul Warrener

TL;DR: Small interfering RNA screens were used to identify genes that enhance the cytotoxicity (enhancers) of established anticancer chemotherapeutics and found tumor cells having disruptions in BRCA1/2 network genes and TP53 together are more sensitive to cisplatin than cells with either disruption alone.

TL;DR: The ability of siRNA-mediated silencing to generate epiallelic hypomorphs associated with KIF14 depletion indicates that distinct stages during cell cycle progression are disrupted by the differential modulation of Kif14 expression.

TL;DR: A cyanobacteria class-3 aldehyde-dehydrogenase, AldE, was discovered that was necessary and sufficient to instead oxidize fatty aldehydes precursors into fatty acids, which may allow biofuel production without transgenesis.

TL;DR: It is discovered that when glycogen synthesis was abolished, by deletion of the gene for glucose-1-phosphate adenylyl transferase (glgC), Synechococcus elongatus PCC 7942 was unable to degrade its phycobilisomes in response to nitrogen stress, and glgC null cells exhibited a non-bleaching phenotype in responseto sulfur and phosphate stress.

TL;DR: The integrated genomic approach has led to the identification of a novel mediator of p53 network biology, which encodes an extracellular heparan sulfate 6-O-endosulfatase that modulates the binding of growth factors to their cognate receptors and that has been shown to function as a tumor suppressor.