M
Mark D. Iafrati
Researcher at Tufts Medical Center
Publications - 99
Citations - 4642
Mark D. Iafrati is an academic researcher from Tufts Medical Center. The author has contributed to research in topics: Venous thrombosis & Chronic venous insufficiency. The author has an hindex of 30, co-authored 91 publications receiving 4224 citations. Previous affiliations of Mark D. Iafrati include Uniformed Services University of the Health Sciences & Tufts University.
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Journal ArticleDOI
Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose
TL;DR: Bone exhibits the most complex spectrum of growth factor activities of any tissue yet described, and mechanisms for unmasking or release of BDGFs from the mineralized matrix resulting in local action on target cells are undoubtedly important for the development and maintenance of bone tissue.
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Estrogen inhibits the vascular injury response in estrogen receptor alpha-deficient mice.
Mark D. Iafrati,Richard H. Karas,Mark Aronovitz,Sung K. Kim,Theodore R. Sullivan,Dennis B. Lubahn,Thomas F. O'Donnell,Kenneth S. Korach,Michael E. Mendelsohn +8 more
TL;DR: It is demonstrated that estrogen inhibits vascular injury by a novel mechanism that is independent of the classic estrogen receptor, ERα, which inhibits the development of atherosclerotic and injury-induced vascular lesions.
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Select Flavonoids and Whole Juice From Purple Grapes Inhibit Platelet Function and Enhance Nitric Oxide Release
Jane E. Freedman,Crawford Parker,Liqing Li,Jacob A. Perlman,Balz Frei,Vadim Ivanov,Leslie R. Deak,Mark D. Iafrati,John D. Folts +8 more
TL;DR: The suppression of platelet-mediated thrombosis represents a potential mechanism for the beneficial effects of purple grape products, independent of alcohol consumption, in cardiovascular disease.
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Stimulation of Toll-Like Receptor 2 in Human Platelets Induces a Thromboinflammatory Response Through Activation of Phosphoinositide 3-Kinase
Price Blair,Sybille Rex,Olga Vitseva,Lea M. Beaulieu,Kahraman Tanriverdi,Subrata Chakrabarti,Chie Hayashi,Caroline A. Genco,Mark D. Iafrati,Jane E. Freedman +9 more
TL;DR: It is demonstrated that human platelets express functional TLR2 capable of recognizing bacterial components and activating the platelet thrombotic and/or inflammatory pathways, and suggests a mechanism by which bacteria could directly activate platelets.
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Controlled release from multilayer silk biomaterial coatings to modulate vascular cell responses.
TL;DR: The results demonstrated that the silk coating system was an effective system for drug-eluting coatings, such as for stent applications, based on its useful micromechanical properties and biological outcomes.