M
Mark E. Scott
Researcher at Merck & Co.
Publications - 32
Citations - 3831
Mark E. Scott is an academic researcher from Merck & Co.. The author has contributed to research in topics: Janus kinase & Ring (chemistry). The author has an hindex of 13, co-authored 32 publications receiving 3600 citations. Previous affiliations of Mark E. Scott include University of Toronto.
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Journal ArticleDOI
Aryl-aryl bond formation by transition-metal-catalyzed direct arylation.
TL;DR: A number of improvements have developed the former process into an industrially very useful and attractive method for the construction of aryl -aryl bonds, but the need still exists for more efficient routes whereby the same outcome is accomplished, but with reduced waste and in fewer steps.
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Process Development of C−N Cross-Coupling and Enantioselective Biocatalytic Reactions for the Asymmetric Synthesis of Niraparib
Cheol K. Chung,Paul G. Bulger,Birgit Kosjek,Kevin M. Belyk,Nelo R. Rivera,Mark E. Scott,Guy R. Humphrey,John Limanto,Donald Bachert,Khateeta M. Emerson +9 more
TL;DR: Process development of the synthesis of the orally active poly(ADP-ribose)polymerase inhibitor niraparib is described, and novel transaminase-mediated dynamic kinetic resolutions of racemic aldehyde surrogates provided enantioselective syntheses of the 3-aryl-piperidine coupling partner.
Journal ArticleDOI
A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress
Katie R. Martin,Stephanie L. Celano,Abigail R. Solitro,Hakan Gunaydin,Mark E. Scott,Ronan C. O'Hagan,Stuart D. Shumway,Peter Fuller,Jeffrey P. MacKeigan,Jeffrey P. MacKeigan +9 more
TL;DR: Two small molecule ULK1 inhibitors are reported, ULK-100 andULK-101, and superior potency and selectivity over a noteworthy published inhibitor are established, and it is demonstrated that ULK 1 inhibition sensitizes KRAS mutant lung cancer cells to nutrient stress.
Journal ArticleDOI
Total synthesis of (-)-(alpha)-kainic acid via a diastereoselective methylenecyclopropane ring expansion.
Mark E. Scott,Mark Lautens +1 more
TL;DR: In this paper, a concise and enantioselective synthesis of (−)-(α)-kainic acid in 13 steps with an overall yield of 15% was reported.
Journal ArticleDOI
A Highly Efficient and Selective Route to Isomeric Cyclic Diazadienes
TL;DR: A highly selective Lewis acid-catalyzed ring expansion of methylenecyclopropyl hydrazones to isomeric cyclic diazadienes is reported.