M
Mark J. Coster
Researcher at Griffith University
Publications - 74
Citations - 1349
Mark J. Coster is an academic researcher from Griffith University. The author has contributed to research in topics: Total synthesis & Aldol reaction. The author has an hindex of 20, co-authored 74 publications receiving 1253 citations. Previous affiliations of Mark J. Coster include Australian National University & University of Queensland.
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Journal ArticleDOI
Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II
Lan-Feng Dong,Victoria J.A. Jameson,David Tilly,Jiri Cerny,Elahe Mahdavian,Alvaro Marín-Hernández,Luz Hernández-Esquivel,Sara Rodríguez-Enríquez,Jan Stursa,Paul K. Witting,Bela Stantic,Jakub Rohlena,Jaroslav Truksa,Katarina Kluckova,Jeffrey Clifford Dyason,Miroslav Ledvina,Brian A. Salvatore,Rafael Moreno-Sánchez,Mark J. Coster,Stephen John Ralph,Robin A.J. Smith,Jiri Neuzil +21 more
TL;DR: It is proposed that mitochondrial targeting of VES with an 11-carbon chain localizes the agent into an ideal position across the interface of the mitochondrial inner membrane and matrix, optimizing its biological effects as an anti-cancer drug.
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Stereocontrolled Total Synthesis of (+)‐Altohyrtin A/Spongistatin 1
Ian Paterson,David Y.-K. Chen,Mark J. Coster,Jose Luis Acena,Jordi Bach,Karl Richard Gibson,Linda E. Keown,Renata M. Oballa,Thomas Trieselmann,Debra J. Wallace,Andrew P. Hodgson,Roger D. Norcross +11 more
TL;DR: A highly stereocontrolled total synthesis, which exploits boron-mediated aldol bond constructions, has been realized to provide, for the first time, a useful amount of synthetic material.
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Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: a new paradigm for effective cancer therapy.
Lan-Feng Dong,Victoria J.A. Jameson,David Tilly,Lubomir Prochazka,Jakub Rohlena,Karel Valis,Jaroslav Truksa,Renata Zobalova,Renata Zobalova,Elahe Mahdavian,Katarina Kluckova,Marina Stantic,Jan Stursa,Ruth Freeman,Paul K. Witting,Erik Norberg,Jacob Goodwin,Brian A. Salvatore,Jana Novotná,Jaroslav Turánek,Miroslav Ledvina,Pavel Hozák,Boris Zhivotovsky,Mark J. Coster,Stephen John Ralph,Robin A.J. Smith,Jiri Neuzil,Jiri Neuzil +27 more
TL;DR: It is proposed that mitochondrially targeted delivery of anti-cancer drugs is enhanced by the addition of a triphenylphosphonium group (TPP(+)), and MitoVES proved superior in suppression of experimental tumors compared to the untargeted analog.
Journal ArticleDOI
A Concise Route to Dihydrobenzo[b]furans: Formal Total Synthesis of (+)-Lithospermic Acid
TL;DR: A sequence of Sonogashira coupling, Pd(II)-catalyzed carbonylative annulation, and benzofuran reduction provides a convergent and modular synthetic route to trans-2-aryl-2,3-dihydrobenzo[b]furan-3-carboxylates, which are a structural feature of numerous biologically active natural products.
Journal ArticleDOI
Mitochondrially targeted α-tocopheryl succinate is antiangiogenic: potential benefit against tumor angiogenesis but caution against wound healing.
Jakub Rohlena,Lan-Feng Dong,Katarina Kluckova,Renata Zobalova,Jacob Goodwin,David Tilly,Jan Stursa,Alena Pecinova,Anatoly A. Philimonenko,Pavel Hozák,Jaideep Banerjee,Miroslav Ledvina,Chandan K. Sen,Josef Houstek,Mark J. Coster,Jiri Neuzil +15 more
TL;DR: It is concluded that MitoVES, a mitochondrially targeted analog of α-tocopheryl succinate, is an efficient antiangiogenic agent of potential clinical relevance, exerting considerably higher activity than its untargeted counterpart.