J
Jaroslav Truksa
Researcher at Academy of Sciences of the Czech Republic
Publications - 54
Citations - 3548
Jaroslav Truksa is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: Hepcidin & Mitochondrion. The author has an hindex of 25, co-authored 51 publications receiving 3007 citations. Previous affiliations of Jaroslav Truksa include Charles University in Prague & Scripps Research Institute.
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Journal ArticleDOI
Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA
An S. Tan,James W. Baty,Lan-Feng Dong,Ayenachew Bezawork-Geleta,Berwini Endaya,Jacob Goodwin,Martina Bajzikova,Jaromira Kovarova,Martin Peterka,Bing Yan,Elham Alizadeh Pesdar,Margarita Sobol,Anatolyj Filimonenko,Shani Stuart,Magdalena Vondrusova,Katarina Kluckova,Karishma Sachaphibulkij,Jakub Rohlena,Pavel Hozák,Jaroslav Truksa,David Eccles,Larisa M. Haupt,Lyn R. Griffiths,Jiri Neuzil,Jiri Neuzil,Michael V. Berridge +25 more
TL;DR: This paper showed that tumor cells without mitochondrial DNA (mtDNA) showed delayed tumor growth, and that tumor formation is associated with acquisition of mtDNA from host cells, leading to partial recovery of mitochondrial function in cells derived from primary tumors grown from cells without mtDNA and a shorter lag in tumor growth.
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The serine protease TMPRSS6 is required to sense iron deficiency.
Xin Du,Ellen She,Terri Gelbart,Jaroslav Truksa,Pauline Lee,Yu Xia,Kevin Khovananth,Suzanne Mudd,Navjiwan Mann,Eva Marie Y Moresco,Ernest Beutler,Bruce Beutler +11 more
TL;DR: The mask phenotype results from reduced absorption of dietary iron caused by high levels of hepcidin and is due to a splicing defect in the transmembrane serine protease 6 gene Tmprss6, an essential component of a pathway that detects iron deficiency and blocks Hamp transcription, permitting enhanced dietary iron absorption.
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Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6
TL;DR: It is shown that the BMP signaling pathway acts independently of Hfe, Tfr2, and IL-6, and all of the tested BMPs are the most potent known stimulators of hepcidin transcription.
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Classification of mitocans, anti-cancer drugs acting on mitochondria.
TL;DR: This communication defines mitocans (many of which have been known for a long time) and classify them into several classes based on their molecular mode of action and chooses the targets that are of major importance from the point of view of their role in mitochondrial destabilisation by small compounds, some of which are now trialled as anti-cancer agents.
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Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells.
Lan-Feng Dong,Jaromira Kovarova,Martina Bajzikova,Ayenachew Bezawork-Geleta,David Svec,Berwini Endaya,Karishma Sachaphibulkij,Ana R Coelho,Ana R Coelho,Natasa Sebkova,Natasa Sebkova,Anna Ruzickova,An S. Tan,Katarina Kluckova,Kristyna Judasova,Katerina Zamecnikova,Zuzana Rychtarcikova,Zuzana Rychtarcikova,Vinod Gopalan,Ladislav Andera,Margarita Sobol,Bing Yan,Bijay Pattnaik,Naveen Kumar Bhatraju,Jaroslav Truksa,Pavel Stopka,Pavel Hozák,Alfred King-Yin Lam,Radislav Sedlacek,Paulo J. Oliveira,Mikael Kubista,Anurag Agrawal,Katerina Dvorakova-Hortova,Katerina Dvorakova-Hortova,Jakub Rohlena,Michael V. Berridge,Jiri Neuzil,Jiri Neuzil +37 more
TL;DR: Results show that intact mitochondria with their mtDNA payload are transferred in the developing tumour, and provide functional evidence for an essential role of oxidative phosphorylation in cancer.