Mark W. Tibbitt

TL;DR: This work presents a strategy for manipulating individual mammalian stem cells in defined synthetic hydrogels through selective optical activation of Rac, which is an intracellular signaling protein that plays a key role in cell migration.

TL;DR: Hydrogel encapsulation improved stability for encapsulated enzymes commonly used in molecular biology (β-galactosidase, alkaline phosphatase, and T4 DNA ligase) following thermal stress, demonstrating a general method to employ reversible polymer networks as robust excipients for thermal stability of complex biologics during storage and shipment that additionally enable on-demand release of active molecules at the point of use.

TL;DR: A tunable organ‐on‐a‐chip model of the retinal microvasculature using human retinalmicrovascular endothelial cells with integrated flow will enable improved understanding of BRB biology and provide an additional tool for drug discovery.

TL;DR: A patterned, immunofunctional, photodegradable PEG hydrogel capture surface is introduced for the isolation and selective release of rare cell populations and provides a micropatternable, cytocompatible platform that imparts the unique ability to recover pure, viable CTC samples by selectively releasing target cells.

TL;DR: In this article, partial swine livers were perfused with autologous blood after being procured from healthy pigs following 70% in-vivo resection, leaving only the right lateral lobe.