Markus Fabits

TL;DR: UL35 is identified as the first HCMV protein to antagonize the type I IFN response at the level of TBK1, thereby enriching the understanding of how this important herpesvirus escapes host immune responses.

TL;DR: The potential of the B7-H6/CD3 ITE to induce T-cell re-directed lysis of tumor cells and recruitment of T cells into non-inflamed tumor tissues leading to anti-tumor activity in in vitro, in vivo, and human tumor slice cultures supports further evaluation in a clinical study.

TL;DR: This work presents a novel and scalable approach that allows us to assess the importance of carrier status and its role in the development of cancerous tumourigenicity.

TL;DR: Pre-treat-ment with the HDACi MS-275 prevented stress-granule aggre-gation and increased the sensitivity of CRC cell lines to oxaliplatin, which induced SG formation in CRC cell-lines and primary tumour tissue culture.

TL;DR: This study provides a sensitive method for detection of neoTCRs and moreover profiling of their activation signatures, and describes a spectrum of qualitatively heterogeneous activation signatures within the neoTCR repertoire of one melanoma patient.