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Andreas Pichlmair
Researcher at Technische Universität München
Publications - 92
Citations - 9267
Andreas Pichlmair is an academic researcher from Technische Universität München. The author has contributed to research in topics: Virus & Viral replication. The author has an hindex of 32, co-authored 76 publications receiving 7434 citations. Previous affiliations of Andreas Pichlmair include Austrian Academy of Sciences & London Research Institute.
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Journal ArticleDOI
RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5' Phosphates
Andreas Pichlmair,Oliver Schulz,Choon Ping Tan,Tanja I. Näslund,Peter Liljeström,Friedemann Weber,Caetano Reis e Sousa +6 more
TL;DR: It is shown that influenza A virus infection does not generate dsRNA and that RIG-I is activated by viral genomic single-stranded RNA (ssRNA) bearing 5′-phosphates, and suggested that its ability to sense 5'-phosphorylated RNA evolved in the innate immune system as a means of discriminating between self and nonself.
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Innate Recognition of Viruses
TL;DR: The sensors involved in coupling recognition of viruses to the induction of the type I IFN genes have only recently been uncovered and include endosomal and cytosolic receptors for RNA and DNA and their properties are reviewed.
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RIG-I detects viral genomic RNA during negative-strand RNA virus infection.
Jan Rehwinkel,Choon Ping Tan,Choon Ping Tan,Delphine Goubau,Oliver Schulz,Andreas Pichlmair,Katja Bier,Nicole C. Robb,Frank T. Vreede,Wendy S. Barclay,Ervin Fodor,Caetano Reis e Sousa +11 more
TL;DR: It is shown that RIG-I agonists are exclusively generated by the process of virus replication and correspond to full-length virus genomes, and nongenomic viral transcripts, short replication intermediates, and cleaved self-RNA do not contribute substantially to interferon induction in cells infected with these negative strand RNA viruses.
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Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection
Andreas Pichlmair,Andreas Pichlmair,Oliver Schulz,Choon-Ping Tan,Jan Rehwinkel,Hiroki Kato,Osamu Takeuchi,Shizuo Akira,Michael Way,Giampietro Schiavo,Caetano Reis e Sousa +10 more
TL;DR: An antibody to dsRNA is used to show that the presence of immunoreactivity in virus-infected cells does indeed correlate with the ability of RNA extracted from these cells to activate MDA5, and suggests that Mda5 activation requires an RNA web rather than simply long molecules of ds RNA.
Journal ArticleDOI
IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA
Andreas Pichlmair,Caroline Lassnig,Carol-Ann Eberle,Maria W. Górna,Christoph Baumann,Thomas R Burkard,Tilmann Bürckstümmer,Adrijana Stefanovic,Sigurd Krieger,Keiryn L. Bennett,Thomas Rülicke,Friedemann Weber,Jacques Colinge,Mathias Müller,Giulio Superti-Furga +14 more
TL;DR: It is proposed that the IFIT complex antagonizes viruses by sequestering specific viral nucleic acids through its binding to PPP-RNA.