J
Jason R. Thomas
Researcher at Novartis
Publications - 38
Citations - 3343
Jason R. Thomas is an academic researcher from Novartis. The author has contributed to research in topics: Protein degradation & RNA. The author has an hindex of 20, co-authored 35 publications receiving 2592 citations. Previous affiliations of Jason R. Thomas include Vertex Pharmaceuticals & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
Targeting RNA with small molecules
TL;DR: A comparison study of RNA binding in NMR-based and electrospray Ionization Mass Spectrometry-Based methods found that the former showed superior results while the latter showed better results in relation to the latter.
Journal ArticleDOI
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
William E. Dowdle,Beat Nyfeler,Jane Nagel,Robert Elling,Shanming Liu,Ellen Triantafellow,Suchithra Menon,Zuncai Wang,Ayako Honda,Gwynn Pardee,John Cantwell,Catherine Luu,Ivan Cornella-Taracido,Edmund Harrington,Peter Fekkes,Hong Lei,Qing Fang,Mary Ellen Digan,Debra Burdick,Andrew F. Powers,Stephen B. Helliwell,Simon D’Aquin,Julie Bastien,Henry Wang,Dmitri Wiederschain,Jenny Kuerth,Philip Bergman,David Schwalb,Jason R. Thomas,Savuth Ugwonali,Fred Harbinski,John A. Tallarico,Christine D. Wilson,Vic E. Myer,Jeffery A. Porter,Dirksen E. Bussiere,Peter Finan,Mark Labow,Xiaohong Mao,Lawrence G. Hamann,Brendan D. Manning,Reginald Valdez,Thomas B. Nicholson,Markus Schirle,Mark Knapp,Erin P. Keaney,Leon Murphy +46 more
TL;DR: a4−/− mice exhibit a profound accumulation of iron in splenic macrophages, which are critical for the reutilization of iron from engulfed red blood cells, and a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo is revealed.
Journal ArticleDOI
Turbostratic1 Boron Nitride, Thermal Transformation to Ordered-layer-lattice Boron Nitride
Journal ArticleDOI
SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice
James Palacino,Susanne E. Swalley,Cheng Song,Atwood K. Cheung,Lei Shu,Xiaolu Zhang,Mailin Van Hoosear,Youngah Shin,Donovan N. Chin,Caroline Gubser Keller,Martin Beibel,Nicole A. Renaud,Thomas M. Smith,Michael Salcius,Xiaoying Shi,Marc Hild,Rebecca Servais,Monish Jain,Lin Deng,Caroline Bullock,Michael McLellan,Sven Schuierer,Leo Murphy,Marcel J. J. Blommers,Cecile Blaustein,Frada Berenshteyn,Arnaud Lacoste,Jason R. Thomas,Guglielmo Roma,Gregory A. Michaud,Brian Tseng,Jeffery A. Porter,Vic E. Myer,John A. Tallarico,Lawrence G. Hamann,Daniel Curtis,Mark C. Fishman,William F. Dietrich,Natalie Dales,Rajeev Sivasankaran +39 more
TL;DR: A potent, orally active, small-molecule enhancer of SMN2 splicing that elevates full-length SMN protein and extends survival in a severe SMA mouse model is described, demonstrating the feasibility of small molecule-mediated, sequence-selective splice modulation and the potential for leveraging this strategy in other splicing diseases.
Journal ArticleDOI
Harnessing the anti-cancer natural product nimbolide for targeted protein degradation
Jessica N. Spradlin,Jessica N. Spradlin,Xirui Hu,Xirui Hu,Carl C. Ward,Carl C. Ward,Scott M. Brittain,Michael D. Jones,Lisha Ou,Lisha Ou,Milton To,Andrew Proudfoot,Elizabeth Ornelas,Mikias Woldegiorgis,James A. Olzmann,Dirksen E. Bussiere,Jason R. Thomas,Jason R. Thomas,John A. Tallarico,Jeffrey Mckenna,Markus Schirle,Thomas J. Maimone,Thomas J. Maimone,Daniel K. Nomura +23 more
TL;DR: It is demonstrated that nimbolide can be harnessed to recruit RNF114 as an E3 ligase in targeted protein degradation applications and show that synthetically simpler scaffolds are also capable of accessing this unique reactive site.