M
Markus Wallwiener
Researcher at Heidelberg University
Publications - 301
Citations - 12267
Markus Wallwiener is an academic researcher from Heidelberg University. The author has contributed to research in topics: Breast cancer & Medicine. The author has an hindex of 34, co-authored 258 publications receiving 5221 citations. Previous affiliations of Markus Wallwiener include University Hospital Heidelberg & University of Tübingen.
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Journal ArticleDOI
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
Andreas D. Hartkopf,Florin-Andrei Taran,Markus Wallwiener,Christina B. Walter,Bernhard K. Krämer,Eva-Maria Grischke,Sara Y. Brucker +6 more
TL;DR: This review summarizes the clinical efficacy, perspectives, and future challenges of using PD-1/PD-L1-directed antibodies in the treatment of breast cancer.
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Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay
Irène Baccelli,Andreas Schneeweiss,Sabine Riethdorf,Albrecht Stenzinger,Anja Schillert,Vanessa Vogel,Vanessa Vogel,Corinna Klein,Massimo Saini,Tobias Bäuerle,Markus Wallwiener,Tim Holland-Letz,Thomas Höfner,Martin R. Sprick,Martina Scharpff,Frederik Marmé,Hans-Peter Sinn,Klaus Pantel,Wilko Weichert,Andreas Trumpp +19 more
TL;DR: It is shown that primary human luminal breast cancer CTCs contain MICs that give rise to bone, lung and liver metastases in mice, and functional circulating MICs and associated markers are described to aid the design of better tools to diagnose and treat metastatic breast cancer.
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Circulating miRNAs as Surrogate Markers for Circulating Tumor Cells and Prognostic Markers in Metastatic Breast Cancer
Dharanija Madhavan,Manuela Zucknick,Markus Wallwiener,Katarina Cuk,Caroline Modugno,Martina Scharpff,Sarah Schott,Joerg Heil,Andrey Turchinovich,Rongxi Yang,Axel Benner,Sabine Riethdorf,Andreas Trumpp,Christof Sohn,Klaus Pantel,Andreas Schneeweiss,Barbara Burwinkel +16 more
TL;DR: This is the first study to document the capacity of circulating miRNAs to indicate CTC status and their potential as prognostic markers in patients with MBC.
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Intra-abdominal adhesions: definition, origin, significance in surgical practice, and treatment options.
Dörthe Brüggmann,Garri Tchartchian,Markus Wallwiener,Karsten Münstedt,Hans-Rudolf Tinneberg,Andreas Hackethal +5 more
TL;DR: Preventive measures include minimizing peritoneal injury intraoperatively through the meticulous observance of basic surgical principles, moistening the mesothelium to keep it from drying out, irrigating the peritoneals to remove blood and clot, and keeping the use of intra-abdominal foreign material to a minimum.
Journal ArticleDOI
Plasma DNA integrity as a biomarker for primary and metastatic breast cancer and potential marker for early diagnosis
Dharanija Madhavan,Dharanija Madhavan,Markus Wallwiener,Karin Bents,Manuela Zucknick,Juliane Nees,Sarah Schott,Katarina Cuk,Katarina Cuk,Sabine Riethdorf,Andreas Trumpp,Klaus Pantel,Christof Sohn,Andreas Schneeweiss,Harald Surowy,Harald Surowy,Barbara Burwinkel,Barbara Burwinkel +17 more
TL;DR: It is shown that reduced cfDI and increased cfDNA concentration can serve as diagnostic markers for PBC and MBC, and cfDI as a prognostic marker for M BC, thereby making them attractive candidates for blood-based multi-marker assays.