Andreas D. Hartkopf

TL;DR: This review summarizes the clinical efficacy, perspectives, and future challenges of using PD-1/PD-L1-directed antibodies in the treatment of breast cancer.

TL;DR: It is shown that progesterone-induced signalling triggers migration of cancer cells from early lesions shortly after HER2 activation, but promotes proliferation in advanced primary tumour cells.

TL;DR: This study demonstrates the histotype-specific nature of immune infiltration and provides definitive evidence for a dose-response relationship between CD8+ TILs and HGSOC survival and suggests that understanding factors that drive infiltration will be the key to unraveling outcome heterogeneity in this cancer.

TL;DR: Adding CTC detection before NCT increased the prognostic ability of multivariable prognostic models for overall survival, distant disease-free survival, and locoregional relapse-free interval and complements current prognosis models based on tumor characteristics and response to therapy.

TL;DR: In this article, the authors evaluated the sizing of primary breast cancer using mammography, sonography and magnetic resonance imaging (MRI) and thereby established which imaging method most accurately corresponds with the size of the histological result.