R
Rongxi Yang
Researcher at Heidelberg University
Publications - 51
Citations - 4731
Rongxi Yang is an academic researcher from Heidelberg University. The author has contributed to research in topics: Breast cancer & DNA methylation. The author has an hindex of 24, co-authored 40 publications receiving 4234 citations. Previous affiliations of Rongxi Yang include University of Erlangen-Nuremberg & Chinese Academy of Sciences.
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Journal ArticleDOI
Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease
Stefan Stein,Marion Ott,Stephan Schultze-Strasser,Anna Jauch,Barbara Burwinkel,Barbara Burwinkel,Andrea Kinner,Manfred Schmidt,Alwin Krämer,Joachim Schwäble,Hanno Glimm,Ulrike Koehl,Carolin Preiss,Claudia R. Ball,Hans Martin,Gudrun Göhring,Kerstin Schwarzwaelder,Wolf K. Hofmann,Kadin Karakaya,Sandrine Tchatchou,Sandrine Tchatchou,Rongxi Yang,Rongxi Yang,Petra Reinecke,Klaus Kühlcke,Brigitte Schlegelberger,Adrian J. Thrasher,Dieter Hoelzer,Reinhard Seger,Christof von Kalle,Manuel Grez +30 more
TL;DR: It is shown that forced overexpression of EVI1 in human cells disrupts normal centrosome duplication, linking EVI 1 activation to the development of genomic instability, monosomy 7 and clonal progression toward myelodysplasia.
Journal ArticleDOI
Tobacco-smoking-related differential DNA methylation: 27K discovery and replication.
Lutz P. Breitling,Rongxi Yang,Rongxi Yang,Bernhard Korn,Barbara Burwinkel,Barbara Burwinkel,Hermann Brenner +6 more
TL;DR: The results, which were based on a rigorous replication approach, show that the gene coding for a potential drug target of cardiovascular importance features altered methylation patterns in smokers.
Journal ArticleDOI
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
Kyriaki Michailidou,Jonathan Beesley,Sara Lindström,Sander Canisius,Joe Dennis,Michael Lush,Mel Maranian,Manjeet K. Bolla,Qin Wang,Mitul Shah,Barbara Perkins,Kamila Czene,Mikael Eriksson,Hatef Darabi,Judith S. Brand,Stig E. Bojesen,Børge G. Nordestgaard,Henrik Flyger,Henrik Flyger,Sune F. Nielsen,Nazneen Rahman,Clare Turnbull,Olivia Fletcher,Julian Peto,Lorna Gibson,Isabel dos-Santos-Silva,Jenny Chang-Claude,Dieter Flesch-Janys,Anja Rudolph,Ursula Eilber,Sabine Behrens,Heli Nevanlinna,Taru A. Muranen,Taru A. Muranen,Kristiina Aittomäki,Kristiina Aittomäki,Carl Blomqvist,Carl Blomqvist,Sofia Khan,Sofia Khan,Kirsimari Aaltonen,Kirsimari Aaltonen,Habibul Ahsan,Muhammad G. Kibriya,Alice S. Whittemore,Esther M. John,Kathleen E. Malone,Marilie D. Gammon,Marilie D. Gammon,Regina M. Santella,Giske Ursin,Giske Ursin,Enes Makalic,Daniel F. Schmidt,Graham Casey,David J. Hunter,Susan M. Gapstur,Mia M. Gaudet,W. Ryan Diver,Christopher A. Haiman,Fredrick R. Schumacher,Brian E. Henderson,Loic Le Marchand,Christine D. Berg,Stephen J. Chanock,Jonine D. Figueroa,Robert N. Hoover,Diether Lambrechts,Patrick Neven,Patrick Neven,Hans Wildiers,Erik Van Limbergen,Marjanka K. Schmidt,Annegien Broeks,Senno Verhoef,Sten Cornelissen,Fergus J. Couch,Janet E. Olson,Emily Hallberg,Emily Hallberg,Emily Hallberg,Celine M. Vachon,Quinten Waisfisz,Quinten Waisfisz,Hanne Meijers-Heijboer,Muriel A. Adank,Rob B. van der Luijt,Jingmei Li,Jianjun Liu,Jianjun Liu,Keith Humphreys,Keith Humphreys,Daehee Kang,Ji Yeob Choi,Sue K. Park,Keun-Young Yoo,Keun-Young Yoo,Keitaro Matsuo,Hidemi Ito,Hiroji Iwata,Kazuo Tajima,Pascal Guénel,Thérèse Truong,Claire Mulot,Marie Sanchez,Barbara Burwinkel,Frederik Marme,Harald Surowy,Christof Sohn,Anna H. Wu,Chiu-Chen Tseng,Chiu-Chen Tseng,David Van Den Berg,Daniel O. Stram,Anna González-Neira,Javier Benitez,M. Pilar Zamora,Jose Ignacio Arias Perez,Xiao-Ou Shu,Xiao-Ou Shu,Wei Lu,Wei Lu,Wei Lu,Yu Tang Gao,Yu Tang Gao,Yu Tang Gao,Hui Cai,Hui Cai,Angela Cox,Simon S. Cross,Malcolm W.R. Reed,Irene L. Andrulis,Julia A. Knight,Julia A. Knight,Gord Glendon,Gord Glendon,Anna Marie Mulligan,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Annika Lindblom,Sara Margolin,Soo Hwang Teo,Cheng Har Yip,Nur Aishah Taib,Gie Hooi Tan,Maartje J. Hooning,Antoinette Hollestelle,John W. M. Martens,J. Margriet Collée,William Blot,Lisa B. Signorello,Qiuyin Cai,John L. Hopper,John L. Hopper,Melissa C. Southey,Helen Tsimiklis,Carmel Apicella,Chen-Yang Shen,Chia-Ni Hsiung,Pei Ei Wu,Pei Ei Wu,Ming-Feng Hou,Vessela N. Kristensen,Silje Nord,Grethe I. Grenaker Alnæs,Graham G. Giles,Roger L. Milne,Catriona McLean,Catriona McLean,Federico Canzian,Federico Canzian,Dimitrios Trichopoulos,Petra P.H. Peeters,Eiliv Lund,Malin Sund,Kay-Tee Khaw,Marc J. Gunter,Domenico Palli,Lotte Maxild Mortensen,Laure Dossus,José María Huerta,José María Huerta,A. Meindl,Rita K. Schmutzler,Christian Sutter,Rongxi Yang,Kenneth Muir,Artitaya Lophatananon,Sarah Stewart-Brown,Sarah Stewart-Brown,Sarah Stewart-Brown,Pornthep Siriwanarangsan,Pornthep Siriwanarangsan,Mikael Hartman,Hui Miao,Kee Seng Chia,Ching Wan Chan,Peter A. Fasching,Alexander Hein,Matthias W. Beckmann,Lothar Haeberle,Hermann Brenner,Aida Karina Dieffenbach,Volker Arndt,Christa Stegmaier,Alan Ashworth,Nick Orr,Minouk J. Schoemaker,Anthony J. Swerdlow,Louise A. Brinton,Montserrat Garcia-Closas,Wei Zheng,Sandra L. Halverson,Martha J. Shrubsole,Martha J. Shrubsole,Jirong Long,Jirong Long,Mark S. Goldberg,Martine Dumont,Robert Winqvist,Katri Pylkäs,Katri Pylkäs,Arja Jukkola-Vuorinen,Arja Jukkola-Vuorinen,Mervi Grip,Mervi Grip,Hiltrud Brauch,Ute Hamann,Thomas Brüning,Paolo Radice,Paolo Peterlongo,Siranoush Manoukian,Loris Bernard,Natalia Bogdanova,Natalia Bogdanova,Thilo Dörk,Thilo Dörk,Arto Mannermaa,Arto Mannermaa,Vesa Kataja,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Peter Devilee,Robert A.E.M. Tollenaar,Caroline M. Seynaeve,Christi J Asperen,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska,Tomasz Huzarski,Suleeporn Sangrajrang,Suleeporn Sangrajrang,Valerie Gaborieau,Paul Brennan,James McKay,Susan L. Slager,Amanda E. Toland,Christine B. Ambrosone,Drakoulis Yannoukakos,Maria Kabisch,Diana Torres,Susan L. Neuhausen,Hoda Anton-Culver,Craig Luccarini,Caroline Baynes,S. Ahmed,Catherine S. Healey,Daniel C. Tessier,Daniel Vincent,Francois Bacot,G Pita,M. Rosario Alonso,Nuria Álvarez,Daniel Herrero,Jacques Simard,Paul D.P. Pharoah,Peter Kraft,Alison M. Dunning,Georgia Chenevix-Trench,Per Hall,Douglas F. Easton +283 more
TL;DR: 15 new loci associated with breast cancer at P < 5 × 10−8 are identified, and one association appears to be driven by an amino acid substitution encoded in EXO1, which is found in women of European ancestry.
Journal ArticleDOI
Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants
Nasim Mavaddat,Paul D.P. Pharoah,Kyriaki Michailidou,Jonathan Tyrer,Mark N. Brook,Mark N. Brook,Manjeet K. Bolla,Qin Wang,Joe Dennis,Alison M. Dunning,Mitul Shah,Robert Luben,Judith E. Brown,Stig E. Bojesen,Børge G. Nordestgaard,Sune F. Nielsen,Henrik Flyger,Kamila Czene,Hatef Darabi,Mikael Eriksson,Julian Peto,Isabel dos-Santos-Silva,Frank Dudbridge,Nichola Johnson,Marjanka K. Schmidt,Annegien Broeks,Senno Verhoef,Emiel J. Th. Rutgers,Anthony J. Swerdlow,Alan Ashworth,Nick Orr,Minouk J. Schoemaker,Jonine D. Figueroa,Stephen J. Chanock,Louise A. Brinton,Jolanta Lissowska,Fergus J. Couch,Janet E. Olson,Celine M. Vachon,Vernon S. Pankratz,Diether Lambrechts,Diether Lambrechts,Hans Wildiers,Chantal Van Ongeval,Erik Van Limbergen,Vessela N. Kristensen,Vessela N. Kristensen,Grethe I. Grenaker Alnæs,Silje Nord,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Heli Nevanlinna,Taru A. Muranen,Kristiina Aittomäki,Carl Blomqvist,Jenny Chang-Claude,Anja Rudolph,Petra Seibold,Dieter Flesch-Janys,Peter A. Fasching,Peter A. Fasching,Lothar Haeberle,Arif B. Ekici,Matthias W. Beckmann,Barbara Burwinkel,Barbara Burwinkel,Frederik Marme,Frederik Marme,Andreas Schneeweiss,Andreas Schneeweiss,Christof Sohn,Amy Trentham-Dietz,Polly A. Newcomb,Polly A. Newcomb,Linda Titus,Kathleen M. Egan,David J. Hunter,David J. Hunter,Sara Lindström,Sara Lindström,Rulla M. Tamimi,Peter Kraft,Peter Kraft,Nazneen Rahman,Clare Turnbull,Anthony Renwick,Sheila Seal,Sheila Seal,Jingmei Li,Jianjun Liu,Keith Humphreys,Javier Benitez,Javier Benitez,M. Pilar Zamora,Jose Ignacio Arias Perez,Primitiva Menéndez,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska-Bieniek,Katarzyna Durda,Natalia Bogdanova,Natalia Bogdanova,Natalia Antonenkova,Thilo Dörk,Hoda Anton-Culver,Susan L. Neuhausen,Argyrios Ziogas,Leslie Bernstein,Peter Devilee,Robert A.E.M. Tollenaar,Caroline M. Seynaeve,Christi J. van Asperen,Angela Cox,Simon S. Cross,Malcolm W.R. Reed,Elza Khusnutdinova,Marina Bermisheva,Marina Bermisheva,Darya Prokofyeva,Zalina Takhirova,Alfons Meindl,Rita K. Schmutzler,Rita K. Schmutzler,Christian Sutter,Rongxi Yang,Rongxi Yang,Peter Schürmann,Michael Bremer,Hans Christiansen,Tjoung Won Park-Simon,Peter Hillemanns,Pascal Guénel,Pascal Guénel,Thérèse Truong,Thérèse Truong,Florence Menegaux,Florence Menegaux,Marie Sanchez,Marie Sanchez,Paolo Radice,Paolo Peterlongo,Siranoush Manoukian,Valeria Pensotti,John L. Hopper,Helen Tsimiklis,Carmel Apicella,Melissa C. Southey,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Thomas Brüning,Yon Ko,Yon Ko,Alice J. Sigurdson,Michele M. Doody,Ute Hamann,Diana Torres,Hans Ulrich Ulmer,Asta Försti,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Irene L. Andrulis,Irene L. Andrulis,Julia A. Knight,Gord Glendon,Anna Marie Mulligan,Anna Marie Mulligan,Georgia Chenevix-Trench,Rosemary L. Balleine,Graham G. Giles,Roger L. Milne,Catriona McLean,Annika Lindblom,Sara Margolin,Christopher A. Haiman,Brian E. Henderson,Fredrick R. Schumacher,Loic Le Marchand,Ursula Eilber,Shan Wang-Gohrke,Maartje J. Hooning,Antoinette Hollestelle,Ans M.W. van den Ouweland,Linetta B. Koppert,Jane Carpenter,Christine L. Clarke,Rodney J. Scott,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Hermann Brenner,Volker Arndt,Christa Stegmaier,Aida Karina Dieffenbach,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Mervi Grip,Kenneth Offit,Kenneth Offit,Joseph Vijai,Joseph Vijai,Mark E. Robson,Rohini Rau-Murthy,Miriam Dwek,Miriam Dwek,Ruth Swann,Katherine Annie Perkins,Mark S. Goldberg,Mark S. Goldberg,Martine Dumont,Diana Eccles,William J. Tapper,Sajjad Rafiq,Esther M. John,Esther M. John,Alice S. Whittemore,Susan L. Slager,Drakoulis Yannoukakos,Amanda E. Toland,Song Yao,Wei Zheng,Sandra L. Halverson,Anna González-Neira,G Pita,M. Rosario Alonso,Nuria Álvarez,Daniel Herrero,Daniel C. Tessier,Daniel Vincent,Francois Bacot,Craig Luccarini,Caroline Baynes,Shahana Ahmed,Mel Maranian,Catherine S. Healey,Jacques Simard,Per Hall,Douglas F. Easton,Montserrat Garcia-Closas +242 more
TL;DR: The PRS stratifies breast cancer risk in women both with and without a family history of breast cancer, and the observed level of risk discrimination could inform targeted screening and prevention strategies.
Journal ArticleDOI
A nuclear function of β-arrestin1 in GPCR signaling : Regulation of histone acetylation and gene transcription
Jiuhong Kang,Yufeng Shi,Bin Xiang,Bin Qu,Wenjuan Su,Min Zhu,Min Zhang,Guobin Bao,Feifei Wang,Xiaoqing Zhang,Rongxi Yang,Fengjuan Fan,Xiaoqing Chen,Gang Pei,Lan Ma +14 more
TL;DR: A novel function of betaarr1 is revealed as a cytoplasm-nucleus messenger in GPCR signaling and an epigenetic mechanism for direct GPCRs signaling from cell membrane to the nucleus through signal-dependent histone modification is elucidated.