M
Marloes van Roijen
Researcher at University of Sydney
Publications - 6
Citations - 88
Marloes van Roijen is an academic researcher from University of Sydney. The author has contributed to research in topics: Disease & Medicine. The author has an hindex of 2, co-authored 3 publications receiving 44 citations.
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Journal ArticleDOI
Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling.
TL;DR: These findings present a potential pathomechanism by which pathological tau interferes with cellular functions through the dysregulation of ribosomal protein synthesis.
Journal ArticleDOI
Increased Tau Phosphorylation in Motor Neurons From Clinically Pure Sporadic Amyotrophic Lateral Sclerosis Patients.
Claire H. Stevens,Claire H. Stevens,Natalie J Guthrie,Natalie J Guthrie,Marloes van Roijen,Glenda M. Halliday,Lezanne Ooi,Lezanne Ooi +7 more
TL;DR: A complex relationship between motor neurons positive for tau phosphorylated at specific residues and disease duration is identified, suggesting that t Tau phosphorylation plays a role in ALS.
Journal ArticleDOI
A Practical Approach to Differentiate the Frontotemporal Tauopathy Subtypes
Shelley L. Forrest,Glenda M. Halliday,Glenda M. Halliday,Anastasia Sizemova,Marloes van Roijen,Ciara V. McGinley,Fiona Bright,Milan Kapur,Andrew B. McGeachie,Andrew B. McGeachie,Heather McCann,Claire E. Shepherd,Claire E. Shepherd,Rachel Tan,Rachel Tan,Andrew J. Affleck,Andrew J. Affleck,Yue Huang,Yue Huang,Yue Huang,Jillian J. Kril +20 more
TL;DR: This study consolidates current consensus diagnostic criteria for classifying FTLD-tau subtypes with an efficient, simple and accurate approach that can be implemented in future clinicopathological studies.
Journal ArticleDOI
Tyrosine phosphatase STEP61 in human dementia and in animal models with amyloid and tau pathology
TL;DR: In this article , the authors examined STEP 61 and its activity in human and animal brain tissue and observed a correlation between STEP 61 activation and disease progression in Alzheimer's and frontotemporal dementia with tau pathology.
Journal ArticleDOI
CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau
Juan Carlos Polanco,Yevhen Akimov,Avinash Fernandes,Adam Briner,Gabriel Rhys Hand,Marloes van Roijen,Giuseppe Balistreri,Jürgen Götz +7 more
TL;DR: Using a genome-wide CRISPRi screen, this paper identified ANKLE2, BANF1, NUSAP1, EIF1AD, and VPS18 as novel regulators of tau pathology induced by both exosome-like extracellular vesicles and free tau seeds.