M
Marta Toth
Researcher at Wayne State University
Publications - 27
Citations - 2375
Marta Toth is an academic researcher from Wayne State University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 18, co-authored 19 publications receiving 2260 citations.
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Book ChapterDOI
Assessment of gelatinases (MMP-2 and MMP-9) by gelatin zymography.
TL;DR: This polyacrylamide gel electrophoresis-based method can provide a reliable assessment of the type of gelatinase, relative amount, and activation status (latent, compared with active enzyme forms) in cultured cells, tissues, and biological fluids.
Journal ArticleDOI
Pro-MMP-9 activation by the MT1-MMP/MMP-2 axis and MMP-3: role of TIMP-2 and plasma membranes.
TL;DR: Investigation of the role of the MT1-MMP/MMP-2 axis and TIMPs in mediating pro- MMP-9 activation shows that TIMP-2 by regulating pro-M MP-2 activation can also act as a positive regulator of pro-mMP- 9 activation.
Journal ArticleDOI
Processing, shedding, and endocytosis of membrane type 1-matrix metalloproteinase (MT1-MMP).
TL;DR: This review will discuss the recent findings concerning mechanisms as diverse as autocatalytic processing, ectodomain shedding, homodimerization and internalization in the context of MT1‐MMP (MMP‐14).
Journal Article
High Levels of Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) Expression Are Associated with Poor Outcome in Invasive Bladder Cancer
David J. Grignon,Wael Sakr,Marta Toth,Vincent Ravery,Javier C. Angulo,Falah Shamsa,J. Edson Pontes,John C. Crissman,Rafael Fridman +8 more
TL;DR: A potential role for TIMP-2 and BM staining as prognostic indicators in invasive bladder cancer is suggested.
Journal ArticleDOI
Regulation of membrane type-matrix metalloproteinases.
TL;DR: This review will focus on new emerging information on the mechanisms that regulate MT-MMP processing, activity and inhibition, and their significance for enzyme function in the tumor microenvironment.