Showing papers by "Martha Skinner published in 1983"
TL;DR: Bleeding occurred frequently in the absence of abnormalities of clotting tests, suggesting that hemorrhage in amyloidosis is most often due to amyloids infiltration of blood vessels.
Abstract: Focal or generalized hemorrhage is a commonly encountered clinical problem in patients with amyloidosis. In 100 patients with amyloidosis, 41 patients experienced one or more bleeding episodes: petechiae and ecchymoses (23), gastrointestinal tract bleeding (18), bleeding after a diagnostic procedure (eight), hematuria (three), hemoptysis (two), and miscellaneous (four). Severe hemorrhage was the cause of death in three patients. Bleeding occurred frequently in the absence of abnormalities of clotting tests, suggesting that hemorrhage in amyloidosis is most often due to amyloid infiltration of blood vessels. In this group of patients, an isolated factor X deficiency was not observed.
197 citations
TL;DR: The needle aspirate of abdominal fat was investigated for its sensitivity in giving a tissue diagnosis in 32 consecutive patients with systemic amyloidosis, and abdominal fat tissue aspiration is proposed as a simple, rapid, and effective technique for the diagnosis of amyloidsosis.
Abstract: • The needle aspirate of abdominal fat was investigated for its sensitivity in giving a tissue diagnosis in 32 consecutive patients with systemic amyloidosis. The fat tissue aspirate was stained with Congo red and examined with a polarizing microscope. Positive results were obtained in 95% (18/19) of patients with primary (AL) amyloidosis, 66% (4/6) of patients with secondary (AA) amyloidosis, and 86% (6/7) of patients with the heredofamilial (AF) form. The overall positive yield was 88% (28/32). Abdominal fat tissue aspiration is proposed as a simple, rapid, and effective technique for the diagnosis of amyloidosis. The prevalence of positive results in known amyloid disease are comparable with the rectal biopsy specimen and are more frequent than gingival or skin biopsy specimens. (Arch Intern Med1983;143:1549-1552)
173 citations
TL;DR: It is concluded that the in vivo asynchrony of the acute phase serum amyloid A and serum isyloid P responses results at least in part from differences in regulatory mechanisms for their synthesis by hepatocytes.
58 citations
Journal Article•
TL;DR: Rate nephelometry is a simple technique that could expand the ability to measure SAP beyond the research setting and can measure this protein more rapidly and reproducibly than previously described methods.
9 citations