A
Antal Rot
Researcher at Queen Mary University of London
Publications - 128
Citations - 15910
Antal Rot is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Chemokine & Chemokine receptor. The author has an hindex of 56, co-authored 119 publications receiving 14707 citations. Previous affiliations of Antal Rot include University of North Carolina at Chapel Hill & Baylor College of Medicine.
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Journal ArticleDOI
Chemokines in Innate and Adaptive Host Defense: Basic Chemokinese Grammar for Immune Cells
Antal Rot,Ulrich H. von Andrian +1 more
TL;DR: This review presents the current understanding of the mechanisms that regulate the cellular perception and pathophysiologic meaning of chemokines and suggests that the specific patterns of homeostatic chemokine patterns are charting lymphocyte navigation routes for immune surveillance.
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CCR7 and its ligands: balancing immunity and tolerance
TL;DR: This work focuses on the cellular and molecular mechanisms that enable CCR7 and its two ligands, CCL19 and CCL21, to balance immunity and tolerance.
Journal ArticleDOI
Transcytosis and Surface Presentation of IL-8 by Venular Endothelial Cells
Jim Middleton,Stuart J. D. Neil,Jonathan Wintle,Ian Clark-Lewis,Moore Henrietta,Charles Lam,Manfred Auer,Elin Hub,Antal Rot +8 more
TL;DR: It is shown by electron microscopy that the prototype chemokine IL-8 is internalized by venular ECs abluminally and transcytosed to the luminal surface, indicating that the described subcellular interactions ofIL-8 with the ECs are functionally relevant.
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International Union of Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors
Françoise Bachelerie,Adit Ben-Baruch,Amanda M. Burkhardt,Christophe Combadière,Joshua M. Farber,Gerard J. Graham,Richard Horuk,Alexander Hovard Sparre-Ulrich,Massimo Locati,Andrew D. Luster,Alberto Mantovani,Kouji Matsushima,Philip M. Murphy,Robert J. B. Nibbs,Hisayuki Nomiyama,Christine Power,Amanda E. I. Proudfoot,Mette M. Rosenkilde,Antal Rot,Silvano Sozzani,Marcus Thelen,Osamu Yoshie,Albert Zlotnik +22 more
TL;DR: This work reviews this extended family of chemokine receptors and Chemokine-binding proteins at the basic, translational, and clinical levels, including an update on drug development and introduces a new nomenclature for atypical chemokin receptors with the stem ACKR (atypicalChemokine receptor).
Journal ArticleDOI
RANTES and macrophage inflammatory protein 1 alpha induce the migration and activation of normal human eosinophil granulocytes.
Antal Rot,Martin Krieger,Thomas Brunner,Stephan C. Bischoff,Thomas J. Schall,Clemens A. Dahinden +5 more
TL;DR: RANTES and MIP-1 alpha are crucial mediators of inflammatory processes in which eosinophils predominate, with kinetics similar to those induced by chemotactic peptides known to interact with G protein-coupled receptors.