M
Martin Howard Infeld
Researcher at Hoffmann-La Roche
Publications - 44
Citations - 1736
Martin Howard Infeld is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Dosage form & Triethyl citrate. The author has an hindex of 18, co-authored 44 publications receiving 1679 citations.
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Journal ArticleDOI
Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs
TL;DR: The ability of polyglycolyzed glycerides (PGG) with varying fatty acid and polyethylene glycol (PEG) chain lengths to produce the self-emulsification of oil in water has been investigated in this paper.
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Properties of hot-melt extruded tablet formulations for the colonic delivery of 5-aminosalicylic acid.
L. Diane Bruce,Navnit Hargovindas Shah,A. Waseem Malick,Martin Howard Infeld,James W. McGinity +4 more
TL;DR: A pre-plasticization step was necessary when incorporating triethyl citrate (TEC) into the formulation in order to achieve uniform mixing of the polymer and plasticizer, effectively reduce the polymer glass transition temperature (T(g)), and to lower the processing temperatures.
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A biodegradable injectable implant for delivering micro and macromolecules using poly (lactic-co-glycolic) acid (PLGA) copolymers
Navnit Hargovindas Shah,A. S. Railkar,F.C. Chen,R. Tarantino,Sunny Kumar,M. Murjani,D. J. Palmer,Martin Howard Infeld,A. W. Malick +8 more
TL;DR: A novel formulation design for a biodegradable injectable implant can provide prolonged release while avoiding the necessity for surgical procedures.
Journal ArticleDOI
Solid-state plasticization of an acrylic polymer with chlorpheniramine maleate and triethyl citrate.
TL;DR: The influence of both CPM and TEC levels on the drug release rate from these polymeric drug delivery systems was shown to be a function of whether the granules or tablets were formed by either hot-melt granulation or hot-Melt extrusion, as well as the plasticization effects of both TEC and CPM on the acrylic polymer.
Journal ArticleDOI
Controlled release of a poorly water-soluble drug from hot-melt extrudates containing acrylic polymers.
TL;DR: Indomethacin (IDM) was found to be both thermally and chemically stable following hot-melt extrusion processing and displayed a plasticizing effect on Eudragit® RL PO as demonstrated by a decrease in the glass transition temperatures of the polymer.