M
Martin N. Kenworthy
Researcher at AstraZeneca
Publications - 2
Citations - 254
Martin N. Kenworthy is an academic researcher from AstraZeneca. The author has an hindex of 2, co-authored 2 publications receiving 144 citations.
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Journal ArticleDOI
Sustainability Challenges in Peptide Synthesis and Purification: From R&D to Production
Albert Isidro-Llobet,Martin N. Kenworthy,Subha Mukherjee,Michael E. Kopach,Katarzyna Wegner,Fabrice Gallou,Austin G. Smith,Frank Roschangar +7 more
TL;DR: The current challenges of peptide synthesis and purification in terms of sustainability are summarized, possible solutions are highlighted, and synergies between academia, the pharmaceutical industry, and contract research organizations/contract manufacturing organizations are encouraged.
Journal ArticleDOI
Use of ω-Transaminase Enzyme Chemistry in the Synthesis of a JAK2 Kinase Inhibitor
Lianne Frodsham,Michael David Golden,Susan Hard,Martin N. Kenworthy,David J. Klauber,Kevin William Leslie,Claire S. MacLeod,Rebecca E. Meadows,Keith R. Mulholland,Julie Reilly,Christopher John Squire,Simone Tomasi,Denise Watt,Andrew S. Wells +13 more
TL;DR: ω-Transaminase enzyme chemistry provides an excellent methodology to build synthetically useful chiral amines from their corresponding ketones, providing a long-term commercial manufacturing route to a JAK2 kinase inhibitor.