F
Frank Roschangar
Researcher at Boehringer Ingelheim
Publications - 82
Citations - 3532
Frank Roschangar is an academic researcher from Boehringer Ingelheim. The author has contributed to research in topics: Catalysis & Aryl. The author has an hindex of 30, co-authored 81 publications receiving 2994 citations. Previous affiliations of Frank Roschangar include Rice University & Scripps Research Institute.
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Journal ArticleDOI
Chemical Biology of Epothilones
TL;DR: This review provides a systematic overview of numerous epothilone analogues that have been modified in the A-D regions in order to obtain information about structure-activity relationships.
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Key Green Chemistry research areas from a pharmaceutical manufacturers’ perspective revisited
Marian C. Bryan,Peter J. Dunn,David Entwistle,Fabrice Gallou,Stefan G. Koenig,John D. Hayler,Matthew R. Hickey,Shaun Hughes,Michael E. Kopach,Gerard Moine,Paul G. Richardson,Frank Roschangar,Alan Steven,Franz J. Weiberth +13 more
TL;DR: In 2007, the members of the ACS Green Chemistry Institute® Pharmaceutical Roundtable assembled a list of key green chemistry research areas to both identify transformations that would benefit from improvements in process greenness and to encourage academic research to this end as mentioned in this paper.
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Overcoming barriers to green chemistry in the pharmaceutical industry – the Green Aspiration Level™ concept
TL;DR: The Green Aspiration Level (GAL) metric as discussed by the authors was proposed as a new process performance metric that quantifies the environmental impact of producing a specific pharmaceutical agent while taking into account the complexity of the ideal synthetic process for producing the target molecule.
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Sustainability Challenges in Peptide Synthesis and Purification: From R&D to Production
Albert Isidro-Llobet,Martin N. Kenworthy,Subha Mukherjee,Michael E. Kopach,Katarzyna Wegner,Fabrice Gallou,Austin G. Smith,Frank Roschangar +7 more
TL;DR: The current challenges of peptide synthesis and purification in terms of sustainability are summarized, possible solutions are highlighted, and synergies between academia, the pharmaceutical industry, and contract research organizations/contract manufacturing organizations are encouraged.
Journal ArticleDOI
Designed Epothilones: Combinatorial Synthesis, Tubulin Assembly Properties, abd Cytotoxic Action against Taxol-Resistant Tumor Cells†
Kyriacos C. Nicolaou,Kyriacos C. Nicolaou,Dionisios Vourloumis,Dionisios Vourloumis,Tianhu Li,Tianhu Li,Joaquin Pastor,Joaquin Pastor,Nicolas Winssinger,Nicolas Winssinger,Yun He,Yun He,S. Ninkovic,S. Ninkovic,F. Sarabia,F. Sarabia,Hans Vallberg,Hans Vallberg,Frank Roschangar,Frank Roschangar,N. Paul King,N. Paul King,M. Ray V. Finlay,M. Ray V. Finlay,Pareskevi Giannakakou,Pascal Verdier-Pinard,Ernest Hamel +26 more
TL;DR: A library of epothilone A and B analogues, which was constructed by solid-phase combinatorial synthesis using SMART Microreactors and solution chemistry, was screened in two different tubulin binding assays and important structure–activity relationship emerged.