M
Martina Wirtz
Researcher at Technische Universität München
Publications - 8
Citations - 671
Martina Wirtz is an academic researcher from Technische Universität München. The author has contributed to research in topics: Biodistribution & Spect imaging. The author has an hindex of 8, co-authored 8 publications receiving 556 citations.
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Journal ArticleDOI
177Lu-Labeled Prostate-Specific Membrane Antigen Radioligand Therapy of Metastatic Castration-Resistant Prostate Cancer: Safety and Efficacy
Richard P. Baum,Harshad R. Kulkarni,Christiane Schuchardt,Aviral Singh,Martina Wirtz,Stefan Wiessalla,Margret Schottelius,Dirk Mueller,Ingo Klette,Hans-Jürgen Wester +9 more
TL;DR: PSMA RLT with 177Lu-PSMA is feasible, safe, and effective in end-stage progressive mCRPC with appropriate selection and follow-up of patients by 68Ga-PSma PET/CT through application of the concept of theranostics.
Journal ArticleDOI
[111In]PSMA-I&T: expanding the spectrum of PSMA-I&T applications towards SPECT and radioguided surgery
TL;DR: [111In]PSMA-I&T shows efficient PSMA targeting in vitro and in vivo, combined with low background accumulation, hinting towards a high value of [111In].
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Value of 111 In-prostate-specific membrane antigen (PSMA)-radioguided surgery for salvage lymphadenectomy in recurrent prostate cancer: correlation with histopathology and clinical follow-up.
Isabel Rauscher,Charlotte Düwel,Martina Wirtz,Margret Schottelius,Hans-Jürgen Wester,Kristina Schwamborn,Bernhard Haller,Markus Schwaiger,Jürgen E. Gschwend,Matthias Eiber,Tobias Maurer +10 more
TL;DR: To evaluate the use of 111In‐labelled prostate‐specific membrane antigen (PSMA)‐I&T‐based radioguided surgery (111In‐PSMA‐RGS) for salvage surgery in recurrent prostate cancer (PCa) using comparison of intra‐operative gamma probe measurements with histopathological results of dissected specimens.
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Intrapatient Comparison of 111In-PSMA I&T SPECT/CT and Hybrid 68Ga-HBED-CC PSMA PET in Patients With Early Recurrent Prostate Cancer.
Isabel Rauscher,Tobias Maurer,Michael Souvatzoglou,Ambros J. Beer,Tibor Vag,Martina Wirtz,Gregor Weirich,Hans-Juergen Wester,Juergen E. Gschwend,Markus Schwaiger,Margret Schottelius,Matthias Eiber +11 more
TL;DR: In a preselected collective of recurrent prostate cancer patients with low PSA values, 111In-PSMA I&T SPECT/CT showed lower detection rates than hybrid 68Ga-HBED-CC PSMA PET but showed a patient based detection rate of 59%, making it a potentially valuable imaging tool where PET is not available apart from its proven value as a PSMA-targeted probe for radioguided surgery.
Journal ArticleDOI
Synthesis and in vitro and in vivo evaluation of urea-based PSMA inhibitors with increased lipophilicity
Martina Wirtz,Alexander Schmidt,Margret Schottelius,Stephanie Robu,Thomas Günther,Markus Schwaiger,Hans-Jürgen Wester +6 more
TL;DR: Higher lipophilicity of the novel PSMA ligands 10 and 11 proved to be beneficial in terms of affinity and internalization and resulted in higher tumor uptake compared to the parent compound, but high renal uptake remains a drawback and further studies are necessary to elucidate the responsible mechanism behind it.