M
Martine Blanche
Researcher at Curie Institute
Publications - 6
Citations - 717
Martine Blanche is an academic researcher from Curie Institute. The author has contributed to research in topics: Neural crest & Trinucleotide repeat expansion. The author has an hindex of 6, co-authored 6 publications receiving 696 citations. Previous affiliations of Martine Blanche include Centre national de la recherche scientifique.
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Journal ArticleDOI
Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans
Armelle Logie,Claire Dunois-Lardé,Christophe Rosty,Olivier Levrel,Martine Blanche,Agnès Ribeiro,Jean-Marie Gasc,José L. Jorcano,Sabine Werner,Xavier Sastre-Garau,Jean Paul Thiery,François Radvanyi +11 more
TL;DR: These findings directly implicate FGFR3 activation as a major cause of benign epidermal tumors in humans.
Journal ArticleDOI
Moderate intergenerational and somatic instability of a 55-CTG repeat in transgenic mice.
Geneviève Gourdon,François Radvanyi,Anne-Sophie Lia,Chantal Duros,Martine Blanche,Marc Abitbol,Claudine Junien,Hlène Hofmann-Radvanyi +7 more
TL;DR: To investigate the role of genomic sequences in instability, transgenic mice containing a 45-kb genomic segment with a 55-CTG repeat cloned from a mildly affected patient showed both intergenerational and somatic repeat instability.
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The human tissue plasminogen activator-Cre mouse: a new tool for targeting specifically neural crest cells and their derivatives in vivo.
TL;DR: This work has established a new transgenic line expressing the Cre recombinase under the control of the human tissue plasminogen activator promoter (Ht-PA), and represents a novel model to specifically target conditional mutations in migratory NCC.
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Lack of β1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype
Marie A. Breau,Thomas Pietri,Olivier Eder,Martine Blanche,Cord Brakebusch,Reinhardt Fässler,Jean P. Thiery,Sylvie Dufour +7 more
TL;DR: Organotypic cultures of gut explants reveal that β1-null enteric neural crest cells show impaired adhesion on extracellular matrix and enhanced intercellular adhesion properties, and display migration defects in collagen gels and gut tissue environments.
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Somatic Instability of the CTG Repeat in Mice Transgenic for the Myotonic Dystrophy Region is Age Dependent But Not Correlated to the Relative Intertissue Transcription Levels and Proliferative Capacities
Anne-Sophie Lia,Hervé Seznec,Hélène Hofmann-Radvanyi,François Radvanyi,Chantal Duros,Céline Saquet,Martine Blanche,Claudine Junien,Geneviève Gourdon +8 more
TL;DR: There is a tendency for repeat length and somatic mosaicism to increase with the age of the mouse and the somatic mutation rates in different tissues were not correlated to the relative inter-tissue difference in transcriptional levels of the three genes surrounding the repeat.