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Xavier Sastre-Garau
Researcher at Curie Institute
Publications - 215
Citations - 14253
Xavier Sastre-Garau is an academic researcher from Curie Institute. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 62, co-authored 213 publications receiving 12896 citations. Previous affiliations of Xavier Sastre-Garau include Versailles Saint-Quentin-en-Yvelines University.
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Journal ArticleDOI
Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas.
David Cappellen,De Oliveira C,David Ricol,de Medina S,Bourdin J,Bourdin J,Xavier Sastre-Garau,Dominique K. Chopin,Jean Paul Thiery,François Radvanyi +9 more
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Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma
Louis Guillou,J.-M. Coindre,Françoise Bonichon,B. Bui Nguyen,P. Terrier,F. Collin,Marie-Odile Vilain,A. M. Mandard,V Le Doussal,A. Leroux,Jocelyne Jacquemier,H Duplay,Xavier Sastre-Garau,J Costa +13 more
TL;DR: The FNCLCC system showed slightly increased ability to predict distant metastasis development and tumor mortality, and the use of this system to evaluate STS aggressiveness might be favored.
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MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data
Matthieu Bui Nguyen Binh,Xavier Sastre-Garau,Louis Guillou,Gonzague de Pinieux,Philippe Terrier,Réal Lagacé,Alain Aurias,Isabelle Hostein,Jean Michel Coindre +8 more
TL;DR: MDM2 and CDK4 immunostainings, which correlate with gene amplification, are helpful adjuncts to differentiate ALT-W DLPS from benign adipose tumors and to separate DDLPS from poorly differentiated sarcomas.
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Ploidy and Large-Scale Genomic Instability Consistently Identify Basal-like Breast Carcinomas with BRCA1/2 Inactivation
Tatiana Popova,Elodie Manié,Guillaume Rieunier,Virginie Caux-Moncoutier,Carole Tirapo,Thierry Dubois,Olivier Delattre,Brigitte Sigal-Zafrani,Marc A. Bollet,Michel Longy,Claude Houdayer,Xavier Sastre-Garau,Anne Vincent-Salomon,Dominique Stoppa-Lyonnet,Marc-Henri Stern +14 more
TL;DR: The genomic signature defined predicted BRCA1/2 inactivation in BLCs with 100% sensitivity and 90% specificity (97% accuracy) may ease the challenge of selecting patients for genetic testing or recruitment to clinical trials of novel emerging therapies that target DNA repair deficiencies in cancer.
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miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response.
Bogdan Mateescu,Bogdan Mateescu,Luciana Batista,Luciana Batista,Melissa Cardon,Melissa Cardon,Tina Gruosso,Tina Gruosso,Yvan de Feraudy,Yvan de Feraudy,Odette Mariani,André Nicolas,Jean-Philippe Meyniel,Paul Cottu,Xavier Sastre-Garau,Fatima Mechta-Grigoriou,Fatima Mechta-Grigoriou +16 more
TL;DR: Show crosstalk between oxidative stress and the miR-200 family of microRNAs that affects tumorigenesis and chemosensitivity and the role of miR200a in stress could be a predictive marker for clinical outcome in ovarian cancer.