Martine Cools

TL;DR: It is hypothesized that gonadoblastomas originate from surviving OCT3/4-positive germ cells in areas of undifferentiated gonadal tissue within the dysgenetic gonad, and supportive evidence was obtained that carcinoma in situ arises in regions with testicular differentiation.

TL;DR: Abnormal OCT3/4 and testis-specific protein Y encoded expression appear to be of pathogenetic relevance in the development of these lesions and are proposed as an alternative for gonadectomy.

TL;DR: Results indicate that GB is a heterogeneous mix of germ cells, in which the OCT3/4-positive cells have the potential to undergo progression to an invasive tumor, and support the model that GB represents the earliest accessible developmental stage of malignant GCTs.

TL;DR: Certain patients with disorders of sex development (DSD), who bear Y chromosome material in their karyotype, are at increased risk for the development of type II germ cell tumors (GCT), which arise from early fetal germ cells.

TL;DR: Two groups of germ cells can be distinguished: Germ cells that are predominantly found in the cortical region of the ovary before weeks 22-24 of gestation, showing an immature phenotype, are mitotically active, and express OCT3/4, a marker of pluripotency, and germ cells undergoing folliculogenesis have lost their pluripotent potential and no longer proliferate.