M
Mary Ann Roberts
Researcher at University of Michigan
Publications - 14
Citations - 1337
Mary Ann Roberts is an academic researcher from University of Michigan. The author has contributed to research in topics: Lyngbya majuscula & Polyketide. The author has an hindex of 10, co-authored 14 publications receiving 1256 citations. Previous affiliations of Mary Ann Roberts include Oregon State University.
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Journal ArticleDOI
Structure and Biosynthesis of the Jamaicamides, New Mixed Polyketide-Peptide Neurotoxins from the Marine Cyanobacterium Lyngbya majuscula
Daniel J. Edwards,Brian L. Marquez,Lisa M. Nogle,Kerry L. McPhail,Douglas E. Goeger,Mary Ann Roberts,William H. Gerwick +6 more
TL;DR: A screening program for bioactive compounds from marine cyanobacteria led to the isolation of jamaicamides A-C, a novel and highly functionalized lipopeptide containing an alkynyl bromide, vinyl chloride, beta-methoxy eneone system, and pyrrolinone ring, giving insight into the mechanism by which this functional group is created.
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Biosynthetic Pathway and Gene Cluster Analysis of Curacin A, an Antitubulin Natural Product from the Tropical Marine Cyanobacterium Lyngbya majuscula†
Zunxue Chang,Namthip Sitachitta,James Rossi,Mary Ann Roberts,Patricia M. Flatt,Junyong Jia,David H. Sherman,William H. Gerwick +7 more
TL;DR: The metabolic system is comprised of a nonribosomal peptide synthetase (NRPS) and multiple polyketide synthases (PKSs) and shows a very high level of collinearity between genes in the cluster and the predicted biochemical steps required for curacin biosynthesis.
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Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
Brian L. Marquez,Karl Shawn Watts,Alexandre F. T. Yokochi,Mary Ann Roberts,Pascal Verdier-Pinard,Jorge I. Jiménez,Ernest Hamel,Paul J. Scheuer,William H. Gerwick +8 more
TL;DR: Hectochlorin shows both a unique profile of cytotoxicity by the COMPARE algorithm and potent inhibitory activity toward the fungus Candida albicans.
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Structure and Absolute Stereochemistry of Phormidolide, a New Toxic Metabolite from the Marine Cyanobacterium Phormidium sp.
R. Thomas Williamson,Anna Boulanger,Alexandra Vulpanovici,Mary Ann Roberts,William H. Gerwick +4 more
TL;DR: The robust number of NMR restraints provided from determination of most homonuclear and heteronuclear coupling constants in phormidolide, along with an abundance of NOE information, allowed construction of a refined lowest energy three-dimensional structure in Macromodel.
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Ypaoamide, a new broadly acting feeding deterrent from the marine cyanobacterium Lyngbya majuscula
TL;DR: Ypaoamide, a new herbivore antifeedent metabolite, was isolated from the extract of a mixed cyanobacteria assemblage which was composed of Schizothrix calcicola and Lyngbya majuscula as mentioned in this paper.