J
James Rossi
Researcher at Oregon State University
Publications - 8
Citations - 519
James Rossi is an academic researcher from Oregon State University. The author has contributed to research in topics: Lyngbya majuscula & Substrate (chemistry). The author has an hindex of 7, co-authored 8 publications receiving 498 citations. Previous affiliations of James Rossi include University of Michigan.
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Journal ArticleDOI
Biosynthetic Pathway and Gene Cluster Analysis of Curacin A, an Antitubulin Natural Product from the Tropical Marine Cyanobacterium Lyngbya majuscula†
Zunxue Chang,Namthip Sitachitta,James Rossi,Mary Ann Roberts,Patricia M. Flatt,Junyong Jia,David H. Sherman,William H. Gerwick +7 more
TL;DR: The metabolic system is comprised of a nonribosomal peptide synthetase (NRPS) and multiple polyketide synthases (PKSs) and shows a very high level of collinearity between genes in the cluster and the predicted biochemical steps required for curacin biosynthesis.
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Biosynthesis of the marine cyanobacterial metabolite barbamide. 1. Origin of the trichloromethyl group
Namthip Sitachitta,James Rossi,Mary Ann Roberts,William H. Gerwick,Matthew D. Fletcher,Christine L. Willis +5 more
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Biosynthetic Pathway and Origin of the Chlorinated Methyl Group in Barbamide and Dechlorobarbamide, Metabolites from the Marine Cyanobacterium Lyngbya majuscula
Namthip Sitachitta,Brian L. Marquez,R. Thomas Williamson,James Rossi,Mary Ann Roberts,William H. Gerwick,Viet-Anh Nguyen,Christine L. Willis +7 more
TL;DR: In this paper, the absolute stereochemistry of the dolaphenine moiety of barbamide was determined to be S, defining the absolute configuration of the barbamide as 2 S,7 S.
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Biosynthesis of radiolabeled curacin A and its rapid and apparently irreversible binding to the colchicine site of tubulin.
Pascal Verdier-Pinard,Namthip Sitachitta,James Rossi,Dan L. Sackett,William H. Gerwick,Ernest Hamel +5 more
TL;DR: It is concluded that curacin A binds more tightly to tubulin than does colchicine, and the covalent bond formation does not occur.
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Pilot scale culture of the marine cyanobacterium Lyngbya majuscula for its pharmaceutically-useful natural metabolite curacin A
TL;DR: A Caribbean collection of Lyngbya majuscula which produces the promising antimitotic agent, curacin A, was recollected in 1993 from Curaçao and adapted to laboratory culture, leading to the selection of one reliable strain, ’19L‘, for further studies.