M
Mary C. Hunt
Researcher at Dublin Institute of Technology
Publications - 11
Citations - 553
Mary C. Hunt is an academic researcher from Dublin Institute of Technology. The author has contributed to research in topics: Peroxisome & Acetylation. The author has an hindex of 9, co-authored 11 publications receiving 471 citations.
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The Peroxisome Proliferator-activated Receptor a (PPARa) Regulates Bile Acid Biosynthesis*
Mary C. Hunt,Yi-Zeng Yang,Claes M. Carneheim,Mats Gåfvels,Curt Einarsson,Stefan E.H. Alexson,Upjohn Ab +6 more
TL;DR: In this article, the peroxisome proliferator-activated receptor a (PPARa) was used to induce sterol 12a-hydroxylase mRNA in liver.
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The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism.
TL;DR: This review will focus on the human and mouse peroxisomal ACOT and acyltransferase enzymes identified to date and discuss their cellular localizations, emerging structural information and functions as auxiliary enzymes in peroxISomal metabolic pathways.
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Regulation of peroxisomal lipid metabolism: the role of acyl-CoA and coenzyme A metabolizing enzymes.
TL;DR: The current view of the role of these auxiliary enzymes in peroxisomal lipid metabolism is reviewed and it is proposed that they function in concert to provide a means to regulate fatty acid metabolism and transport of products across the per oxisomal membrane.
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Targeting the Folate Receptor: Improving Efficacy in Inorganic Medicinal Chemistry
Pauraic Mc Carron,Aisling Crowley,Denis O'Shea,Malachy McCann,Orla Howe,Mary C. Hunt,Michael Devereux +6 more
TL;DR: The literature pertaining to non-platinum metal complex conjugates with folic acid is reviewed revealing that this is an area that offers significant potential to develop targeted therapeutic approaches in areas such as chemotherapy and molecular imaging for diagnostics.
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Disarming Pseudomonas aeruginosa Virulence by the Inhibitory Action of 1,10-Phenanthroline-5,6-Dione-Based Compounds: Elastase B (LasB) as a Chemotherapeutic Target
Anna Clara M. Galdino,Livia Viganor,Alexandre A. de Castro,Elaine F. F. da Cunha,Thaís P. Mello,Larissa Maura Melo Mattos,Marcos D. Pereira,Mary C. Hunt,Megan O’Shaughnessy,Orla Howe,Michael Devereux,Malachy McCann,Teodorico C. Ramalho,Marta H. Branquinha,André L.S. Santos +14 more
TL;DR: Evaluated compounds reinforced the concept of lasB being a veritable therapeutic target and phendione-based compounds (mainly Cu-phendione) being prospective anti-virulence drugs against P. aeruginosa and protective action for lung epithelial cells.