M
Marina I. Siponen
Researcher at Structural Genomics Consortium
Publications - 6
Citations - 372
Marina I. Siponen is an academic researcher from Structural Genomics Consortium. The author has contributed to research in topics: TAF1 & Binding site. The author has an hindex of 5, co-authored 5 publications receiving 315 citations. Previous affiliations of Marina I. Siponen include Karolinska Institutet.
Papers
More filters
Journal ArticleDOI
The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism.
TL;DR: This review will focus on the human and mouse peroxisomal ACOT and acyltransferase enzymes identified to date and discuss their cellular localizations, emerging structural information and functions as auxiliary enzymes in peroxISomal metabolic pathways.
Journal ArticleDOI
Comparative structural analysis of lipid binding START domains.
Ann-Gerd Thorsell,Wen Hwa Lee,Camilla Persson,Marina I. Siponen,Martina Nilsson,Robert D. Busam,T. Kotenyova,Herwig Schüler,Lari Lehtiö,Lari Lehtiö +9 more
TL;DR: In this paper, the structural determinants of human START domains are defined, both those related to structural framework and those involved in ligand specificity, and sequence alignments based on these and previously reported crystal structures define the structure of human STARD domains.
Journal ArticleDOI
High-resolution structure of TBP with TAF1 reveals anchoring patterns in transcriptional regulation
Madhanagopal Anandapadamanaban,Cecilia Andrésen,Sara Helander,Yoshifumi Ohyama,Marina I. Siponen,Patrik Lundström,Tetsuro Kokubo,Mitsuhiko Ikura,Martin Moche,Maria Sunnerhagen +9 more
TL;DR: It is found that yeast TAF1-TAND1, which in itself acts as a transcriptional activator, binds TBP's concave DNA-binding surface by presenting similar anchor residues to TBP as does Mot1 but from a distinct structural scaffold.
Journal ArticleDOI
Structural Determination of Functional Domains in Early B-cell Factor (EBF) Family of Transcription Factors Reveals Similarities to Rel DNA-binding Proteins and a Novel Dimerization Motif.
Marina I. Siponen,Magdalena Wisniewska,Lari Lehtiö,Ida Johansson,Linda Svensson,Grzegorz Raszewski,Lennart Nilsson,Mikael Sigvardsson,Helena Berglund +8 more
TL;DR: The data presented here provide insights into unique structural features of the EBF proteins and open possibilities for detailed molecular investigations of this important transcription factor family.
Journal ArticleDOI
Structural basis for regulation of the human acetyl-CoA thioesterase 12 and interactions with the steroidogenic acute regulatory protein-related lipid transfer (START) domain
Crystall M.D. Swarbrick,Noelia Roman,Nathan Cowieson,Edward I Patterson,Jeffrey D. Nanson,Marina I. Siponen,Helena Berglund,Lari Lehtiö,Jade K. Forwood +8 more
TL;DR: It is demonstrated that ACOT12 is a trimer rather than a tetramer and that neither ADP nor ATP exert their regulatory effects by altering the oligomeric status of the enzyme.