M
Mary Claire Kennedy
Researcher at Medical College of Wisconsin
Publications - 32
Citations - 4387
Mary Claire Kennedy is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Aconitase & Substrate (chemistry). The author has an hindex of 27, co-authored 32 publications receiving 4197 citations. Previous affiliations of Mary Claire Kennedy include University of Wisconsin-Madison.
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Journal ArticleDOI
Aconitase as iron-sulfur protein, enzyme, and iron-regulatory protein
TL;DR: Primary sequence data indicate the versatility of the aconitase fold in carrying out a 2370 Chemical Reviews, 1996, Vol.
Journal ArticleDOI
The role of iron in the activation-inactivation of aconitase.
TL;DR: It is concluded that, in analogy to cluster loss during activation in absence of added iron, the appearance of 59Fe in more than one cluster site can be due to complete breakdown and rebuilding of clusters, and exchange into intact clusters cannot be ruled out.
Journal ArticleDOI
Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein
TL;DR: The amino acid composition, molecular weight, isoelectric point, and the sequences of six random peptides clearly show that these physicochemical and structural characteristics are identical to those of IRE-BP, and that c-aconitase is distinctly different from m-aconitic aconitase.
Journal ArticleDOI
DNA Binding and Dimerization of the Fe−S-containing FNR Protein from Escherichia coli Are Regulated by Oxygen
TL;DR: Observations suggest that oxygen regulates the activity of wild-type FNR through the lability of the Fe-S cluster to oxygen.
Journal ArticleDOI
Mitochondrial Aconitase Is a Source of Hydroxyl Radical: AN ELECTRON SPIN RESONANCE INVESTIGATION
TL;DR: Evidence for the generation of ⋅OH from the reaction of m-aconitase with superoxide is provided using ESR spin trapping experiments with 5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide and α-phenyl-N-tert-butylnitrone.