M
Masafumi Koshiyama
Researcher at Kyoto University
Publications - 55
Citations - 1746
Masafumi Koshiyama is an academic researcher from Kyoto University. The author has contributed to research in topics: Sex hormone receptor & Ovarian cancer. The author has an hindex of 20, co-authored 52 publications receiving 1451 citations. Previous affiliations of Masafumi Koshiyama include University of Shiga Prefecture.
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Journal ArticleDOI
Expression of Vascular Endothelial Growth Factor in Ovarian Cancer Inhibits Tumor Immunity through the Accumulation of Myeloid-Derived Suppressor Cells
Naoki Horikawa,Kaoru Abiko,Noriomi Matsumura,Junzo Hamanishi,Tsukasa Baba,Ken Yamaguchi,Yumiko Yoshioka,Masafumi Koshiyama,Ikuo Konishi +8 more
TL;DR: VEGF expression in ovarian cancer induced MDSCs, inhibited local immunity, and contributed to poor prognosis, according to Clin Cancer Res; 23(2); 587–99.
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Recent Concepts of Ovarian Carcinogenesis: Type I and Type II
TL;DR: Type I ovarian tumors, where precursor lesions in the ovary have clearly been described, include endometrioid, clear cell, mucinous, low grade serous, and transitional cell carcinomas, while type II tumor types, where such lesions have not been described clearly and tumors may develop de novo from the tubal and/or ovarian surface epithelium, comprise high gradeserous carcinomas and carcinosarcomas.
Journal Article
Expression of Metastasis-related nm23-H1 and nm23-H2 Genes in Ovarian Carcinomas: Correlation with Clinicopathology, EGFR, c-erbB-2, and c-erbB-3 Genes, and Sex Steroid Receptor Expression
Masaki Mandai,Ikuo Konishi,Masafumi Koshiyama,Takahide Mori,Shinji Arao,Hironori Tashiro,Hitoshi Okamura,Hiroshi Nomura,Hiroshi Hiai,Manabu Fukumoto +9 more
TL;DR: In this paper, the role of metastasis-related nm23 genes in carcinogenesis and progression of ovarian carcinoma was verified by analyzing the mRNA levels of the nm23-H1 genes of both isoforms, -H1 and -H2, together with those of the epidermal growth factor receptor, the c- erb B-2, and the c - erbB-3 genes in 45 ovarian carcinomas and 5 benign cystadenomas.
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Exome Sequencing Landscape Analysis in Ovarian Clear Cell Carcinoma Shed Light on Key Chromosomal Regions and Mutation Gene Networks.
Ryusuke Murakami,Noriomi Matsumura,Noriomi Matsumura,J.B. Brown,Koichiro Higasa,Takanobu Tsutsumi,Mayumi Kamada,Hisham A. Abou-Taleb,Yuko Hosoe,Sachiko Kitamura,Ken Yamaguchi,Kaoru Abiko,Junzo Hamanishi,Tsukasa Baba,Masafumi Koshiyama,Yasushi Okuno,Ryo Yamada,Fumihiko Matsuda,Ikuo Konishi,Masaki Mandai,Masaki Mandai +20 more
TL;DR: In this paper, the authors performed whole exome sequencing of 39 ovarian clear cell carcinoma (OCCC) samples with 16 matching blood tissue samples and detected mutations in MLL3 (15%), ARID1B (10%), and PIK3R1 (8%), which are associations not previously reported.
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Subtypes of Ovarian Cancer and Ovarian Cancer Screening
TL;DR: Current issues, the efficacy and problems associated with ovarian cancer screening, and the characteristics of ovarian cancer subtypes are discussed, and biomarkers for the early detection of Type II carcinomas such as STICs need to be developed.