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Naoki Horikawa
Researcher at Kyoto University
Publications - 19
Citations - 1499
Naoki Horikawa is an academic researcher from Kyoto University. The author has contributed to research in topics: Ovarian cancer & Medicine. The author has an hindex of 7, co-authored 15 publications receiving 1041 citations.
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Journal ArticleDOI
IFN-γ From Lymphocytes Induces PD-L1 Expression and Promotes Progression of Ovarian Cancer
Kaoru Abiko,Noriomi Matsumura,Junzo Hamanishi,Naoki Horikawa,Ryusuke Murakami,Ken Yamaguchi,Yumiko Yoshioka,Tsukasa Baba,Ikuo Konishi,Masaki Mandai +9 more
TL;DR: The lymphocyte infiltration and the IFN-γ status may be the key to effective anti- PD-1 or anti-PD-L1 therapy in ovarian cancer.
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Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer
Jin Peng,Junzo Hamanishi,Noriomi Matsumura,Kaoru Abiko,Kumuruz Murat,Tsukasa Baba,Ken Yamaguchi,Naoki Horikawa,Yuko Hosoe,Susan K. Murphy,Ikuo Konishi,Masaki Mandai +11 more
TL;DR: It is found that chemotherapy induces local immune suppression in ovarian cancer through NF-κB-mediated PD-L1 upregulation and a combination of chemotherapy and immunotherapy targeting the PD- L1/PD-1 signaling axis may improve the antitumor response and offers a promising new treatment modality against ovarian cancer.
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Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation.
Mana Taki,Kaoru Abiko,Tsukasa Baba,Junzo Hamanishi,Ken Yamaguchi,Ryusuke Murakami,Koji Yamanoi,Naoki Horikawa,Yuko Hosoe,Eijiro Nakamura,Aiko Sugiyama,Masaki Mandai,Ikuo Konishi,Noriomi Matsumura +13 more
TL;DR: It is shown that, in the mesenchymal subtype of ovarian cancer, Snail expression promotes tumorigenesis by inducing immune evasion through CXCR2-ligands-mediated recruitment of myeloid-derived suppressor cells.
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Expression of Vascular Endothelial Growth Factor in Ovarian Cancer Inhibits Tumor Immunity through the Accumulation of Myeloid-Derived Suppressor Cells
Naoki Horikawa,Kaoru Abiko,Noriomi Matsumura,Junzo Hamanishi,Tsukasa Baba,Ken Yamaguchi,Yumiko Yoshioka,Masafumi Koshiyama,Ikuo Konishi +8 more
TL;DR: VEGF expression in ovarian cancer induced MDSCs, inhibited local immunity, and contributed to poor prognosis, according to Clin Cancer Res; 23(2); 587–99.
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VISTA expressed in tumour cells regulates T cell function
Kumuluzi Mulati,Junzo Hamanishi,Noriomi Matsumura,Kenji Chamoto,Nathan Mise,Kaoru Abiko,Tsukasa Baba,Ken Yamaguchi,Naoki Horikawa,Ryusuke Murakami,Mana Taki,Kharma Budiman,Xiang Zeng,Yuko Hosoe,Miyuki Azuma,Ikuo Konishi,Masaki Mandai +16 more
TL;DR: This is the first demonstration that VISTA is highly expressed in human ovarian and endometrial cancer cells, and that anti-VISTA antibody treatment significantly prolongs the survival of mice bearing tumour-bearing mice.