M
Masaharu Kotani
Researcher at Institute of Medical Science
Publications - 63
Citations - 2100
Masaharu Kotani is an academic researcher from Institute of Medical Science. The author has contributed to research in topics: Ganglioside & Monoclonal antibody. The author has an hindex of 25, co-authored 63 publications receiving 2019 citations. Previous affiliations of Masaharu Kotani include Hiroshima University & Ohu University.
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Characterization of the rat leukocyte integrin, CD11/CD18, by the use of LFA-1 subunit-specific monoclonal antibodies.
TL;DR: The conclusion that the mAb WT.1 and WT.3 specifically recognize the rat CD11a and CD18, respectively, was based on their ability to inhibit homotypic aggregation of splenic concanavalin A (Con A) blasts and their blocking abilities in mixed leukocyte reaction.
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ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth
TL;DR: It is shown that mAb16-39 elicits tyrosine phosphorylation of endogenously expressed ALK in human neuroblastoma (SK-N-SH) cells, indicating an essential role of the mitogen-activated protein kinase (MAP kinase) signaling cascade in ALK-mediated growth and differentiation of neurons.
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Generation of one set of monoclonal antibodies specific for a-pathway ganglio-series gangliosides
TL;DR: Six murine monoclonal antibodies specific for b-pathway ganglio-series gangliosides were established by immunizing C3H/HeN mice with these purified gangLiosides adsorbed to Salmonella minnesota mutant R595 and determined the expression of these ganglioides, especially GD1b, GT1b and GQ1b on mouse, rat, and human leukemia cells.
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Differential distribution of major gangliosides in rat central nervous system detected by specific monoclonal antibodies
TL;DR: It is found that there is a cell type-specific expression of the ganglioside in the rat central nervous system and in other regions, such as hippocampal formation and spinal cord, the expression was also highly localized to a specific cell type and layer.
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Comparison of the effects of agalsidase alfa and agalsidase beta on cultured human Fabry fibroblasts and Fabry mice
Hitoshi Sakuraba,Mai Murata-Ohsawa,Ikuo Kawashima,Youichi Tajima,Masaharu Kotani,Toshio Ohshima,Yasunori Chiba,Minako Takashiba,Yoshifumi Jigami,Tomoko Fukushige,Tamotsu Kanzaki,Kohji Itoh +11 more
TL;DR: An immunocytochemical analysis revealed that the incorporated recombinant enzyme degraded the globotriaosyl ceramide accumulated in cultured Fabry fibroblasts in a dose-dependent manner, with the effect being maintained for at least 7 days.