M
Masaharu Takigawa
Researcher at Okayama University
Publications - 381
Citations - 16788
Masaharu Takigawa is an academic researcher from Okayama University. The author has contributed to research in topics: CTGF & Chondrocyte. The author has an hindex of 67, co-authored 368 publications receiving 15664 citations. Previous affiliations of Masaharu Takigawa include Kyoto Prefectural University of Medicine & University of Tokushima.
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Journal ArticleDOI
Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model.
Toshifumi Mori,Shigeru Kawara,Mikio Shinozaki,Nobukazu Hayashi,Takashi Kakinuma,Atsuyuki Igarashi,Masaharu Takigawa,Toru Nakanishi,Kazuhiko Takehara +8 more
TL;DR: It appears that interaction of several growth factors is required for persistent fibrotic tissue formation, with TGF‐β causing the induction and CTGF needed for maintenance of skin fibrosis.
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A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis
Yoshinari Miyamoto,Akihiko Mabuchi,Dongquan Shi,Toshikazu Kubo,Yoshio Takatori,Susumu Saito,Mikihiro Fujioka,Akihiro Sudo,Atsumasa Uchida,Seizo Yamamoto,Koichi Ozaki,Masaharu Takigawa,Toshihiro Tanaka,Yusuke Nakamura,Qing Jiang,Shiro Ikegawa +15 more
TL;DR: It is suggested that decreased GDF5 expression is involved in the pathogenesis of osteoarthritis because of allelic differences on transcriptional activity in chondrogenic cells, with the susceptibility allele showing reduced activity.
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Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo.
Tsuyoshi Shimo,Tohru Nakanishi,Takashi Nishida,Masahiro Asano,Manabu Kanyama,Takuo Kuboki,Takuya Tamatani,Katsunari Tezuka,Motohide Takemura,Tomohiro Matsumura,Masaharu Takigawa +10 more
TL;DR: Findings indicate that CTGF is a novel, potent angiogenesis factor which functions in multi-stages in this process.
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Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes
Kazuhiro Sasaki,Takako Hattori,Takuo Fujisawa,Kojiro Takahashi,Hajime Inoue,Masaharu Takigawa +5 more
TL;DR: E elevation of the NO level via iNOS mRNA expression stimulated by IL-1 mediates gene expression and production of MMPs and bFGF, resulting in the release of bF GF, and also reveal molecular mechanisms implicating the degradation of articular cartilage followed by angiogenesis in the synovium in arthritic joints.
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Reduction in Connective Tissue Growth Factor by Antisense Treatment Ameliorates Renal Tubulointerstitial Fibrosis
Hideki Yokoi,Masashi Mukoyama,Tetsuya Nagae,Kiyoshi Mori,Takayoshi Suganami,Kazutomo Sawai,Tetsuro Yoshioka,Masao Koshikawa,Takashi Nishida,Masaharu Takigawa,Akira Sugawara,Kazuwa Nakao +11 more
TL;DR: Findings indicate that CTGF expression in the interstitium plays a crucial role in the progression of interstitial fibrosis but not in the proliferation of tubular and interstitial cells during UUO, and may become a potential therapeutic target against tubulointerstitial fibrosis.