M
Masahiko Yamamoto
Researcher at Aichi Gakuin University
Publications - 114
Citations - 5265
Masahiko Yamamoto is an academic researcher from Aichi Gakuin University. The author has contributed to research in topics: Neurotrophic factors & Glial cell line-derived neurotrophic factor. The author has an hindex of 37, co-authored 111 publications receiving 4896 citations. Previous affiliations of Masahiko Yamamoto include Nagoya University.
Papers
More filters
Journal ArticleDOI
Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy
Mei Li,Shigeru Miwa,Y. Kobayashi,Y. Kobayashi,Diane E. Merry,Masahiko Yamamoto,Fumiaki Tanaka,Manabu Doyu,Yoshio Hashizume,Kenneth H. Fischbeck,Gen Sobue +10 more
TL;DR: In the motor neurons of SBMA patients, there were AR‐immunoreactive ubiquitinated nuclear inclusions that were detected by antibodies that recognize a small portion of the N terminus of the AR protein.
Journal ArticleDOI
Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.
Tsuyoshi Yoshihara,Shinsuke Ishigaki,Masahiko Yamamoto,Yideng Liang,Jun-ichi Niwa,Hideyuki Takeuchi,Manabu Doyu,Gen Sobue +7 more
TL;DR: In this paper, the molecular mechanism underlying motor neuron degeneration in the transgenic mouse model expressing the SOD1 gene with G93A mutation was analyzed using cDNA microarray.
Journal ArticleDOI
Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues.
TL;DR: The spatial patterns of the distributions of neurotrophic factors and their receptors mRNA levels in the adult human PNS and nonneural tissues are largely similar to those reported in other mammals, but these findings provide further, more specific, understanding relevant to the therapeutic approach to human diseases.
Journal ArticleDOI
Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis
Yue-Mei Jiang,Masahiko Yamamoto,Yasushi Kobayashi,Tsuyoshi Yoshihara,Yideng Liang,Shin-ichi Terao,Hideyuki Takeuchi,Shinsuke Ishigaki,Masahisa Katsuno,Hiroaki Adachi,Jun-ichi Niwa,Fumiaki Tanaka,Manabu Doyu,Mari Yoshida,Yoshio Hashizume,Gen Sobue +15 more
TL;DR: The motor neuron–specific gene expression profile in sporadic ALS can provide direct information on the genes leading to neurodegeneration and neuronal death and are helpful for developing new therapeutic strategies.
Journal ArticleDOI
Type I (transthyretin Met30) familial amyloid polyneuropathy in Japan: early- vs late-onset form.
Haruki Koike,Ken Ichiro Misu,Shu-ichi Ikeda,Yukio Ando,Masamitsu Nakazato,Eiko Ando,Masahiko Yamamoto,Naoki Hattori,Gen Sobue +8 more
TL;DR: Differences in clinical and geographic features between early- and late-onset FAP TTR Met30 were confirmed and it was confirmed that late-ONSet cases may be more prevalent and widespread than previously believed.